TRPM7 regulates angiotensin II-induced sinoatrial node fibrosis in sick sinus syndrome rats by mediating Smad signaling
Sign Up to like & getrecommendations! Published in 2018 at "Heart and Vessels"
DOI: 10.1007/s00380-018-1146-0
Abstract: Sinoatrial node fibrosis is involved in the pathogenesis of sinus sick syndrome (SSS). Transient receptor potential (TRP) subfamily M member 7 (TRPM7) is implicated in cardiac fibrosis. However, the mechanisms underlying the regulation of sinoatrial… read more here.
Keywords: sinoatrial node; trpm7; fibrosis; sss ... See more keywords
Downregulation of TRPM7 suppressed migration and invasion by regulating epithelial–mesenchymal transition in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Medical Oncology"
DOI: 10.1007/s12032-017-0987-1
Abstract: Metastasis is a leading cause of death in patients with prostate cancer (PCa). Transient receptor potential channel 7 (TRPM7) functions as a Mg2+/Ca2+-permeable channel as well as a protein kinase that regulate various cellular processes… read more here.
Keywords: pca; trpm7; migration invasion; pca cells ... See more keywords
Investigating Phosphorylation Patterns of the Ion Channel TRPM7 Using Multiple Extraction and Enrichment Techniques Reveals New Phosphosites
Sign Up to like & getrecommendations! Published in 2019 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-019-02223-5
Abstract: AbstractThe study of membrane proteins, and in particular ion channels, is crucial to understanding cellular function. Mass spectrometry-based approaches including bottom-up strategies to study membrane proteins have been successful yet still can remain challenging. In… read more here.
Keywords: trpm7; phosphorylation patterns; ion channel; patterns ion ... See more keywords
Molecular expression of Mg2+ regulator TRPM7 and CNNM4 in rat odontoblasts.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2018.09.011
Abstract: OBJECTIVE Magnesium, the second most abundant cation in cellular fluid, is critical for mineralization of hard tissues. Among the molecules involved in cellular Mg2+ homeostasis, functional impairment of Mg2+ permeable ion channel TRPM7 or Mg2+… read more here.
Keywords: rat odontoblasts; trpm7 cnnm4; trpm7; expression ... See more keywords
Suppression of cortical TRPM7 protein attenuates oxidative damage after traumatic brain injury via Akt/endothelial nitric oxide synthase pathway
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.07.010
Abstract: &NA; Neuronal death after traumatic brain injury (TBI) is a complex process resulting from a combination of factors, many of which are still unknown. Transient receptor potential melastatin 7 (TRPM7) is a transient receptor potential… read more here.
Keywords: suppression; trpm7; trpm7 suppression; brain ... See more keywords
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-019-0304-z
Abstract: Sepsis is the main cause of mortality in patients admitted to intensive care units. During sepsis, endothelial permeability is severely augmented, contributing to renal dysfunction and patient mortality. Ca 2+ influx and the subsequent increase… read more here.
Keywords: kidney injury; trpm7; hyperpermeability; dysfunction ... See more keywords
Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42739
Abstract: TRPM7 and TRPM6 were the first identified bifunctional channels to contain their own kinase domains, but how these channel-kinases are regulated is poorly understood. Previous studies identified numerous phosphorylation sites on TRPM7, but very little… read more here.
Keywords: trpm7; mass spectrometric; trpm6; spectrometric analysis ... See more keywords
LPS promotes the progression of sepsis by activation of lncRNA HULC/miR-204-5p/TRPM7 network in HUVECs
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20200740
Abstract: Abstract Sepsis is a systemic inflammatory response syndrome caused by infection. Lipopolysaccharide (LPS) has been reported to induce inflammatory responses, and long non-coding RNA highly up-regulated in liver cancer (HULC) expression was associated with the… read more here.
Keywords: mir 204; sepsis; hulc; trpm7 ... See more keywords
Structure of the mammalian TRPM7, a magnesium channel required during embryonic development
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1810719115
Abstract: Significance Ion channels are pore-forming proteins spanning biological membranes. Transient receptor potential ion channels are a subclass of ion channel proteins, characterized by nonselective permeability to cations such as sodium, calcium, magnesium, and zinc, and… read more here.
Keywords: channel; ion channel; trpm7; embryonic development ... See more keywords
TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aaw4847
Abstract: The ion channel TRPM7 mediates Ca2+ fluctuations in growth plate chondrocytes that are needed for proper bone growth. Ca2+ fluctuations promote growth plate chondrogenesis In the growth plates of long bones, ordered arrays of chondrocytes… read more here.
Keywords: trpm7; growth plate; bone; plate chondrocytes ... See more keywords
Mechanism of Stat1 in the neuronal Ca2+ overload after intracerebral hemorrhage via the H3K27ac/Trpm7 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00083.2022
Abstract: Intracerebral hemorrhage (ICH) is classified as a subtype of stroke and Calcium (Ca2+) overload is a catalyst for ICH. This study explored the mechanisms of Stat1 (signal transducer and activator of transcription 1) in the… read more here.
Keywords: neuronal ca2; trpm7; h3k27ac; ca2 overload ... See more keywords