The cation channel TRPM8 influences the differentiation and function of human monocytes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1hi0421-181r
Abstract: Monocytes are mononuclear phagocytes that can differentiate to a variety of cell fates under the influence of their microenvironment and hardwired commitment. We found that inhibition of TRPM8 in human blood CD14+ monocytes during a… read more here.
Keywords: cation channel; function; trpm8; trpm8 influences ... See more keywords
Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.03.017
Abstract: TRPM8 is the main ion channel responsible for cold transduction in the somatosensory system. Nerve terminal availability of TRPM8 determines cold sensitivity, but how axonal secretory organelles control channel delivery remains poorly understood. Here we… read more here.
Keywords: organelles control; non conventional; ion channel; trpm8 ... See more keywords
Menthol-induced activation of TRPM8 receptors increases cutaneous blood flow across the dermatome.
Sign Up to like & getrecommendations! Published in 2021 at "Microvascular research"
DOI: 10.1016/j.mvr.2021.104271
Abstract: Topical menthol-based analgesics increase skin blood flow (SkBF) through transient receptor potential melastatin 8 (TRPM8) receptor-dependent activation of sensory nerves and endothelium-derived hyperpolarization factors. It is unclear if menthol-induced TRPM8 activation mediates a reflex change… read more here.
Keywords: across dermatome; menthol induced; blood; activation ... See more keywords
Cellular permeation of large molecules mediated by TRPM8 channels
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.063
Abstract: While most membrane channels are only capable of passing small ions, certain non-selective cation channels have been recently shown to have the capacity to permeate large cations. The mechanisms underlying large molecule permeation are unclear,… read more here.
Keywords: permeation large; large molecules; trpm8 channels; mediated trpm8 ... See more keywords
Vagus nerve is involved in the changes in body temperature induced by intragastric administration of 1,8-cineole via TRPM8 in mice
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.04.018
Abstract: Transient Receptor Potential Melastatin 8 (TRPM8) is a cold receptor activated by mild cold temperature ( read more here.
Keywords: trpm8; nerve involved; intragastric administration; administration cineole ... See more keywords
ADP-Ribose and oxidative stress activate TRPM8 channel in prostate cancer and kidney cells
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-37552-0
Abstract: Activation of TRPM8 channel through oxidative stress may induce Ca2+ and pro-apoptotic signals in prostate cancer and kidney cells. The aim of this study was to evaluate activation of TRPM8 can increase apoptosis and oxidative… read more here.
Keywords: activation; trpm8; prostate cancer; oxidative stress ... See more keywords
Therapeutic potential of TRPM8 antagonists in prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02675-4
Abstract: Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate cancer, although its mechanism of action remains unclear. Here, we have characterized and investigated the effects of TRPM8 modulators in prostate cancer aggressiveness disclosing… read more here.
Keywords: cancer; trpm8; androgen; receptor ... See more keywords
TRPM8 in the negative regulation of TNFα expression during cold stress
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45155
Abstract: Transient Receptor Potential Melastatin-8 (TRPM8) reportedly plays a fundamental role in a variety of processes including cold sensation, thermoregulation, pain transduction and tumorigenesis. However, the role of TRPM8 in inflammation under cold conditions is not… read more here.
Keywords: tnf; cold stress; expression; trpm8 negative ... See more keywords
Transient receptor potential melastatin 8 (TRPM8) is required for nitroglycerin and calcitonin gene-related peptide induced migraine-like pain behaviors in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002635
Abstract: ABSTRACT Migraine is a complex neurovascular disorder that is one of the leading causes of disability and a reduced quality of life. Even with such a high societal impact, our understanding of the cellular and… read more here.
Keywords: migraine like; migraine; trpm8; like pain ... See more keywords
TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15960
Abstract: Transient receptor potential melastatin type‐8 (TRPM8) is a cold‐sensitive cation channel protein belonging to the TRP superfamily of ion channels. Here, we reveal the molecular mechanism of TRPM8 and its clinical relevance in colorectal cancer… read more here.
Keywords: indicates poor; trpm8; poor prognosis; trpm8 indicates ... See more keywords
Responding to the cold
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.365.6460.1414-k
Abstract: Structural Biology Mint tastes cool because the active component, menthol, activates the receptor and calcium channel TRPM8, which also responds to cold temperatures. Previous structures have revealed the architecture of TRPM8 and how it binds… read more here.
Keywords: microscopy; science; responding cold; biology ... See more keywords