Identification of herbal components as TRPA1 agonists and TRPM8 antagonists.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural medicines"
DOI: 10.1007/s11418-021-01515-z
Abstract: Transient receptor potential (TRP) channels are non-selective cation channels that are implicated in analgesia, bowel motility, wound healing, thermoregulation, vasodilation and voiding dysfunction. Many natural products have been reported to affect the activity of TRP… read more here.
Keywords: trp channels; agonists trpm8; flavonoid aglycones; trpm8 antagonists ... See more keywords
Identification of Cannabigerol-Derived Dual CB2 Receptor Agonists and TRPM8 Antagonists with Anti-Inflammatory and Analgesic Activities.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c03220
Abstract: Emerging evidence suggests that compounds possessing both CB2 receptor (CB2R) agonist and TRPM8 antagonist activities may offer effective pain relief while minimizing the severe side effects commonly associated with current analgesics. In this study, we… read more here.
Keywords: agonists trpm8; inflammatory analgesic; trpm8 antagonists; cb2 receptor ... See more keywords