Exploration of TRPM8 Binding Sites by β-Carboline-Based Antagonists and Their In Vitro Characterization and In Vivo Analgesic Activities
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DOI: 10.1021/acs.jmedchem.0c00816
Abstract: Transient receptor potential melastatin 8 (TRPM8) ion channel represents a valuable pharmacological option for several therapeutic areas. Here, a series of conformationally restricted derivatives of the previously described TRPM8 antagonist N,N′-dibenzyl tryptophan 4 were prepared… read more here.
Keywords: vivo; trpm8 binding; binding sites; sites carboline ... See more keywords