Cellular permeation of large molecules mediated by TRPM8 channels
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.063
Abstract: While most membrane channels are only capable of passing small ions, certain non-selective cation channels have been recently shown to have the capacity to permeate large cations. The mechanisms underlying large molecule permeation are unclear,… read more here.
Keywords: permeation large; large molecules; trpm8 channels; mediated trpm8 ... See more keywords
Transient receptor potential melastatin 8 (TRPM8) is required for nitroglycerin and calcitonin gene-related peptide induced migraine-like pain behaviors in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002635
Abstract: ABSTRACT Migraine is a complex neurovascular disorder that is one of the leading causes of disability and a reduced quality of life. Even with such a high societal impact, our understanding of the cellular and… read more here.
Keywords: migraine like; migraine; trpm8; like pain ... See more keywords
Therapeutic potential of TRPM8 channels in cancer treatment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1098448
Abstract: Cancer is a multifactorial process associated with changes in signaling pathways leading to cell cycle variations and gene expression. The transient receptor potential melastatin 8 (TRPM8) channel is a non-selective cation channel expressed in neuronal… read more here.
Keywords: potential trpm8; therapeutic potential; channels cancer; trpm8 channels ... See more keywords
TRPM8 Channels and Dry Eye
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceuticals"
DOI: 10.3390/ph11040125
Abstract: Transient receptor potential (TRP) channels transduce signals of chemical irritation and temperature change from the ocular surface to the brain. Dry eye disease (DED) is a multifactorial disorder wherein the eyes react to trivial stimuli… read more here.
Keywords: channels dry; eye; trpm8 channels; dry eye ... See more keywords