Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy
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DOI: 10.1007/s00395-022-00930-x
Abstract: Accumulating evidence suggests that autophagy dysfunction plays a critical role in myocardial ischemia/reperfusion (I/R) injury. However, the underling mechanism of malfunctional autophagy in the cardiomyocytes subjected to I/R has not been well defined. As a… read more here.
Keywords: injury; autophagic flux; trpml1; ischemia reperfusion ... See more keywords
A lysosomal K+ channel regulates large particle phagocytosis by facilitating lysosome Ca2+ release
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DOI: 10.1038/s41598-020-57874-2
Abstract: Macrophages are highly specialized in removing large particles including dead cells and cellular debris. When stimulated, delivery of the intracellular lysosomal membranes is required for the formation of plasmalemmal pseudopods and phagosomes. As a key… read more here.
Keywords: particle phagocytosis; particle; trpml1; ca2 ... See more keywords
Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P2 and rapamycin
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DOI: 10.1073/pnas.2120404119
Abstract: Significance Rapamycin is a specific inhibitor of mammalian target of rapamycin (mTOR). Rapamycin can also activate transient receptor potential mucolipin 1 (TRPML1), a phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2]–gated lysosomal cation channel whose loss-of-function mutations directly cause mucolipidosis… read more here.
Keywords: trpml1; microscopy; trpml1 rapamycin; rapamycin ... See more keywords
Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259455
Abstract: ABSTRACT Liver cancers, including hepatocellular carcinoma (HCC), are the second leading cause of cancer death worldwide, and novel therapeutic strategies are still highly needed. Recently, the endolysosomal cation channel TRPML1 (also known as MCOLN1) has… read more here.
Keywords: hepatocellular carcinoma; function; trpml1; mitochondrial function ... See more keywords