Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P2 and rapamycin
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DOI: 10.1073/pnas.2120404119
Abstract: Significance Rapamycin is a specific inhibitor of mammalian target of rapamycin (mTOR). Rapamycin can also activate transient receptor potential mucolipin 1 (TRPML1), a phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2]–gated lysosomal cation channel whose loss-of-function mutations directly cause mucolipidosis… read more here.
Keywords: trpml1; microscopy; trpml1 rapamycin; rapamycin ... See more keywords