The intracellular Ca2+ channel TRPML3 is a PI3P effector that regulates autophagosome biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200085119
Abstract: Significance Autophagy involves multiple fusion events, from autophagosome formation to autophagosome-lysosome fusion in a Ca2+-dependent manner. Fundamental unanswered issue- in the autophagy field is how Ca2+ is provided for autophagic membrane fusion. Here, we report… read more here.
Keywords: pi3p; trpml3; effector; channel ... See more keywords
TRPML3-mediated lysosomal Ca2+ release enhances drug sequestration and biogenesis, promoting osimertinib resistance in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2025 at "Oncology Reports"
DOI: 10.3892/or.2025.8946
Abstract: Lysosomes and lysosomal Ca2+ play crucial roles in cellular homeostasis and drug resistance. The lysosomal Ca2+ channel transient receptor potential mucolipin 3 (TRPML3; also known as mucolipin-3 or MCOLN3) is a key regulator of autophagy… read more here.
Keywords: resistance; drug; cell; lysosomal ca2 ... See more keywords