Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha‐Synuclein and Enhance Therapy of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202108435
Abstract: Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by enhancing the autophagy of microglia to phagocytose and degrade α‐syn via… read more here.
Keywords: parkinson disease; trpv1 channels; syn; alpha synuclein ... See more keywords
Molecular modeling and chemometric analysis of osteoporosis calmodulin‐TRPV1 binding affinity by statistically characterizing complex interactions
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemometrics"
DOI: 10.1002/cem.2989
Abstract: The intermolecular interaction among the calcium sensor, calmodulin (CaM), and the C‐terminal domain of its cognate partner, transient receptor potential vanilloid 1 (TRPV1), plays a potential role in bone absorption and loss, which has been… read more here.
Keywords: trpv1; modeling chemometric; molecular modeling; trpv1 binding ... See more keywords
p70S6K on astrocytes protects dopamine neurons from 1‐methyl‐4‐phenylpyridinium neurotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24013
Abstract: Our recent finding has demonstrated that astrocytes confer neuroprotection by endogenously producing ciliary neurotrophic factor (CNTF) via transient receptor potential vanilloid 1 (TRPV1) in Parkinson's disease (PD). In this study, the possible molecular target for… read more here.
Keywords: trpv1; p70s6k signaling; p70s6k astrocytes; p70s6k ... See more keywords
Inhibition of transient receptor potential vanilloid 1 (TRPV1) channel regulates chikungunya virus infection in macrophages
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Virology"
DOI: 10.1007/s00705-020-04852-8
Abstract: Chikungunya virus (CHIKV), a virus that induces pathogenic inflammatory host immune responses, is re-emerging worldwide, and there are currently no established antiviral control measures. Transient receptor potential vanilloid 1 (TRPV1), a non-selective Ca 2+ -permeable… read more here.
Keywords: trpv1; infection; inhibition; chikv infection ... See more keywords
Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-017-9407-8
Abstract: A recent hypothesis suggesting that the pharmacological target TRPV1 (transient receptor potential vanilloid subfamily, member 1) may function as a tumour suppressor, which potentially impacts the development of TRPV1 antagonist therapeutics for a range of… read more here.
Keywords: trpv1; risk; trpv1 antagonists; vitro vivo ... See more keywords
Extra-endothelial TRPV1 channels participate in alcohol and caffeine actions on cerebral artery diameter.
Sign Up to like & getrecommendations! Published in 2018 at "Alcohol"
DOI: 10.1016/j.alcohol.2018.04.002
Abstract: Alcohol (ethyl alcohol; ethanol) and caffeine are the two most widely used psychoactive substances in the world. Caffeine and ethanol have both been reported to constrict cerebral arteries in several species, including humans. We have… read more here.
Keywords: ethanol caffeine; trpv1; caffeine; constriction ... See more keywords
Red-hot chili receptors: A systematic review of TRPV1 antagonism in animal models of psychiatric disorders and addiction
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112734
Abstract: Transient Receptor Potential Vanilloid 1 (TRPV1) channels are non-selective cationic polymodal receptors gated by several different chemical and physical stimuli. TRPV1 receptors are distributed in several brain areas and interact with important neurotransmitter systems linked… read more here.
Keywords: trpv1; red hot; hot chili; animal models ... See more keywords
Sensation of TRPV1 via 5-hydroxytryptamine signaling modulates pain hypersensitivity in a 6-hydroxydopamine induced mice model of Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.204
Abstract: Parkinson's disease (PD) related pain can be assigned to either nociceptive pain or neuropathic pain, in which Transient receptor potential vanilloid 1 (TRPV1) has been demonstrated to play a pivotal role. Yet little research has… read more here.
Keywords: mice model; trpv1; pain; parkinson disease ... See more keywords
Menthol relieves acid reflux inflammation by regulating TRPV1 in esophageal epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.050
Abstract: Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays an important role in pain and inflammatory responses. Previous studies have shown that the expression of TRPV1 increases in the sensory neurons of the… read more here.
Keywords: trpv1; epithelial cells; trpv1 esophageal; expression trpv1 ... See more keywords
Stimulation of TRPV1 channels activates the AP‐1 transcription factor
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.02.008
Abstract: Graphical abstract Figure. No Caption available. Abstract Transient receptor potential vanilloid 1 (TRPV1) channels were originally described as the receptors of capsaicin, the main constituent of hot chili pepper. The biological functions of TRPV1 channels… read more here.
Keywords: trpv1; transcription; stimulation trpv1; trpv1 channels ... See more keywords
Temperature-Sensitive Gating of TRPV1 Channel as Probed by Atomistic Simulations
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2738
Abstract: Heat-activated transient receptor potential channel TRPV1 is one of the most studied eukaryotic proteins involved in temperature sensation. Upon heating, it exhibits rapid reversible pore gating, which depolarizes neurons and generates action potentials. Underlying molecular… read more here.
Keywords: sensitive gating; gating trpv1; trpv1; channel ... See more keywords