TRPV1 antagonist BCTC inhibits pH 6.0-induced pain in human skin.
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DOI: 10.1097/j.pain.0000000000001848
Abstract: Tissue acidosis due to ischemia occurs under several pathological conditions, and is thought to contribute to pain in these circumstances. TRPV1, TRPA1 and ASICs are known to be sensitive to acidic pH. Addressing their possible… read more here.
Keywords: induced pain; trpv1 antagonist; skin; bctc inhibits ... See more keywords
NEO6860, modality-selective TRPV1 antagonist: a randomized, controlled, proof-of-concept trial in patients with osteoarthritis knee pain
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DOI: 10.1097/pr9.0000000000000696
Abstract: Introduction: NEO6860 is a TRPV1 antagonist when activated by capsaicin but not by heat or pH, developed to relieve pain without the adverse events reported with non–modality-selective TRPV1 antagonists. Objective: The primary Objective of this… read more here.
Keywords: patients osteoarthritis; trpv1 antagonist; selective trpv1; osteoarthritis knee ... See more keywords
Novel therapeutic approach with PAC‐14028 cream, a TRPV1 antagonist, for patients with mild‐to‐moderate atopic dermatitis
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.17777
Abstract: This issue of the BJD includes a potentially important study concerning a new topical treatment for atopic dermatitis (AD), which is characterized by significant pruritus, a key feature of AD. While the precise mechanism of… read more here.
Keywords: trpv1; dermatology; trpv1 antagonist; treatment ... See more keywords
Scalable Synthesis of TRPV1 Antagonist Bipyridinyl Benzimidazole Derivative via the Suzuki–Miyaura Reaction and Selective SeO2 Oxidation
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DOI: 10.3390/molecules28020836
Abstract: In this study, a kilogram-scale synthesis of a potent TRPV1 antagonist, 1, is described. To synthesize bipyridinyl benzimidazole derivative 1, we have developed a scalable Suzuki–Miyaura reaction capable of providing a key intermediate, 6′-methyl-3-(trifluoromethyl)-2,3′-bipyridine 4,… read more here.
Keywords: oxidation; reaction; trpv1 antagonist; suzuki miyaura ... See more keywords