Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment
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DOI: 10.1007/s10565-017-9407-8
Abstract: A recent hypothesis suggesting that the pharmacological target TRPV1 (transient receptor potential vanilloid subfamily, member 1) may function as a tumour suppressor, which potentially impacts the development of TRPV1 antagonist therapeutics for a range of… read more here.
Keywords: trpv1; risk; trpv1 antagonists; vitro vivo ... See more keywords
Turning up the heat on surgical cold
Sign Up to like & getrecommendations! Published in 2017 at "Temperature"
DOI: 10.1080/23328940.2017.1319453
Abstract: Wouldn’t it be great to be able to develop a completely new drug for less than $60 million in 6 years or less? And to solve a problem associated with significant morbidity (intraoperative hypothermia) during… read more here.
Keywords: hypothermia; approval; trpv1 antagonists; drug ... See more keywords