Robust expression of SIRT6 inhibits pulpitis via activation of the TRPV1 channel
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3528
Abstract: Invasion of dentinal tubules and pulp tissue by pathogenic bacteria may cause infection leading to pulpitis. Sirtuin 6 (SIRT6) is a NAD‐dependent protein deacetylase encoded by the SIRT6 gene. The effect of SIRT6 on lipopolysaccharide… read more here.
Keywords: pulpitis; sirt6; trpv1 channel; pulp ... See more keywords
Cholesterol as a Key Molecule That Regulates TRPV1 Channel Function.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-14265-0_6
Abstract: Cholesterol is the one of the major constituents of cell membranes providing these structures with a certain degree of rigidity. Proteins, such as ion channels, are molecules inserted in cell membranes and their activity is… read more here.
Keywords: ion channels; cholesterol; cholesterol key; trpv1 channel ... See more keywords
Dexmedetomidine Relieves Acute Inflammatory Visceral Pain in Rats through the ERK Pathway, Toll-Like Receptor Signaling, and TRPV1 Channel
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1172-5
Abstract: Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor agonist. In this study, we aimed to characterize the antinociceptive effects of DEX in acute inflammatory visceral pain (AIVP) induced by acetic acid in rats and… read more here.
Keywords: acute inflammatory; dex; trpv1 channel; erk pathway ... See more keywords
Differences in the effects of four TRPV1 channel antagonists on lipopolysaccharide-induced cytokine production and COX-2 expression in murine macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.173
Abstract: Sepsis is a systemic inflammatory response syndrome triggered by lipopolysaccharide (LPS), an outer membrane component of gram-negative bacteria, and cytokine production via LPS-induced macrophage activation is deeply involved in its pathogenesis. Effective therapy of sepsis… read more here.
Keywords: channel antagonists; cox; expression; trpv1 channel ... See more keywords
Temperature-Sensitive Gating of TRPV1 Channel as Probed by Atomistic Simulations
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2738
Abstract: Heat-activated transient receptor potential channel TRPV1 is one of the most studied eukaryotic proteins involved in temperature sensation. Upon heating, it exhibits rapid reversible pore gating, which depolarizes neurons and generates action potentials. Underlying molecular… read more here.
Keywords: sensitive gating; gating trpv1; trpv1; channel ... See more keywords
Probing temperature and capsaicin-induced activation of TRPV1 channel via computationally guided point mutations in its pore and TRP domains.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.04.239
Abstract: In a recent computational study, we revealed some mechanistic aspects of TRPV1 (transient receptor potential channel 1) thermal activation and gating and proposed a set of probable functionally important residues - "hot spots" that have… read more here.
Keywords: channel; trpv1 channel; activation; capsaicin induced ... See more keywords
A new coumarin from Murraya alata activates TRPV1 channel
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1548455
Abstract: Abstract One new coumarin, muralatin R, was isolated from the leaves of Murraya alata Drake (Rutaceae). Its structure was elucidated by extensive analysis of the NMR and MS data, along with the specific rotation comparison.… read more here.
Keywords: new coumarin; coumarin murraya; trpv1 channel; alata activates ... See more keywords
Bibliometric analysis of recent research on the association between TRPV1 and inflammation
Sign Up to like & getrecommendations! Published in 2023 at "Channels"
DOI: 10.1080/19336950.2023.2189038
Abstract: ABSTRACT TRPV1 channel is a sensitive ion channel activated by some noxious stimuli and has been reported to change many physiological functions after its activation. In this paper, we present a scientometric approach to explore… read more here.
Keywords: inflammation; research; association trpv1; trpv1 channel ... See more keywords
TRPV1 Channel Activated by the PGE2/EP4 Pathway Mediates Spinal Hypersensitivity in a Mouse Model of Vertebral Endplate Degeneration
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/9965737
Abstract: Low back pain (LBP) is the primary cause of disability globally. There is a close relationship between Modic changes or endplate defects and LBP. Endplates undergo ossification and become highly porous during intervertebral disc (IVD)… read more here.
Keywords: trpv1; drg neurons; lsi mice; trpv1 channel ... See more keywords
TRPV1 channel in spermatozoa is a molecular target for ROS-mediated sperm dysfunction and differentially expressed in both natural and ART pregnancy failure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.867057
Abstract: Bi-directional crosstalk between Ca2+ signaling and ROS modulates physiological processes as a part of a regulatory circuit including sperm function. The role of transient receptor potential vanilloid 1 (TRPV1) in this regard cannot be undermined.… read more here.
Keywords: sperm dysfunction; trpv1 channel; pregnancy; trpv1 ... See more keywords
Transient Receptor Potential Vanilloid1 (TRPV1) Channel Opens Sesame of T Cell Responses and T Cell-Mediated Inflammatory Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.870952
Abstract: Transient receptor potential vanilloid1 (TRPV1) was primarily expressed in sensory neurons, and could be activated by various physical and chemical factors, resulting in the flow of extracellular Ca2+ into cells. Accumulating data suggest that the… read more here.
Keywords: cell; vanilloid1 trpv1; transient receptor; receptor potential ... See more keywords