Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha‐Synuclein and Enhance Therapy of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202108435
Abstract: Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by enhancing the autophagy of microglia to phagocytose and degrade α‐syn via… read more here.
Keywords: parkinson disease; trpv1 channels; syn; alpha synuclein ... See more keywords
Stimulation of TRPV1 channels activates the AP‐1 transcription factor
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.02.008
Abstract: Graphical abstract Figure. No Caption available. Abstract Transient receptor potential vanilloid 1 (TRPV1) channels were originally described as the receptors of capsaicin, the main constituent of hot chili pepper. The biological functions of TRPV1 channels… read more here.
Keywords: trpv1; transcription; stimulation trpv1; trpv1 channels ... See more keywords
Imaging with Ion Channels.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c00224
Abstract: We describe the incorporation of gated ion channels into probes for scanning ion conductance microscopy (SICM) as a robust platform for collecting spatial information at interfaces. Specifically, a dual-barrel pipet is used, where one barrel… read more here.
Keywords: imaging ion; microscopy; ion channels; barrel ... See more keywords
The role of TRPV1 channels in atherosclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Channels"
DOI: 10.1080/19336950.2020.1747803
Abstract: ABSTRACT Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a nonselective cation channel, that is mainly distributed in sensory nerve endings and can release a variety of neurotransmitters after activation. Early studies showed that… read more here.
Keywords: trpv1; channels atherosclerosis; trpv1 channels; role ... See more keywords
TRPV1 channels as a newly identified target for vitamin D
Sign Up to like & getrecommendations! Published in 2021 at "Channels"
DOI: 10.1080/19336950.2021.1905248
Abstract: ABSTRACT Vitamin D is known to elicit many biological effects in diverse tissue types and is thought to act almost exclusively upon its canonical receptor within the nucleus, leading to gene transcriptional changes and the… read more here.
Keywords: trpv1; newly identified; trpv1 channels; channels newly ... See more keywords
A Review on Potential Involvement of TRPV1 Channels in Ischemia–Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology and Therapeutics"
DOI: 10.1177/1074248417707050
Abstract: Besides functioning as thermosensors, transient receptor potential vanilloid 1 (TRPV1) channels play a pivotal role in ischemia–reperfusion injury. Transient receptor potential vanilloid 1 channel activation attenuates ischemia–reperfusion-induced injury in various organs including the heart, lungs,… read more here.
Keywords: ischemia reperfusion; reperfusion injury; injury; trpv1 channels ... See more keywords