5-Alkoxy-1-aryl-3-polyfluoroalkylpyrazoles with Antinociceptive Activity: Partial Agonists of TRPV1 Ion Channels.
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DOI: 10.1002/cmdc.202300063
Abstract: Chemoselective O-alkylation of 1-aryl-3-polyfluoroalkylpyrazol-5-oles under basic conditions resulted in a series of 5-alkoxypyrazoles (26 derivatives). They were showed to have an acceptable ADME profile (in silico). In experiments in vivo (CD-1 mice), it was found… read more here.
Keywords: partial agonists; trpv1 ion; agonists trpv1; aryl polyfluoroalkylpyrazoles ... See more keywords
Analysis of the Involvement of NMDA Receptors in Analgesia and Hypothermia Induced by the Activation of TRPV1 Ion Channels
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DOI: 10.32607/actanaturae.11829
Abstract: NMDA glutamate receptors play an important role in normal and pathophysiological nociception. At the periphery, they can interact with TRPV1 ion channels. The blockade of TRPV1 ion channels decreases NMDA-induced hyperalgesia, and NMDA receptor antagonists… read more here.
Keywords: nmda receptors; trpv1 ion; ion channels; capsaicin ... See more keywords