Opposing roles of dorsomedial hypothalamic CB1 and TRPV1 receptors in anandamide signaling during the panic-like response elicited in mice by Brazilian rainbow Boidae snakes
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-5170-2
Abstract: RationaleThe endocannabinoid system plays an important role in the organization of panic-like defensive behavior. Threatening situations stimulate brain areas, such as the dorsomedial hypothalamus (DMH). However, there is a lack of studies addressing the role… read more here.
Keywords: effect; dmh; trpv1 receptors; panic like ... See more keywords
Alkylamides from Acmella oleracea: antinociceptive effect and molecular docking with cannabinoid and TRPV1 receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2142221
Abstract: Alkylamides are secondary metabolites in Acmella oleracea and display wide applications in treating several diseases. Since alkylamides can inhibit pain, this work aims to evaluate the antinociceptive profile of A. Oleracea methanolic extracts used in vivo… read more here.
Keywords: molecular docking; trpv1 receptors; oleracea antinociceptive; acmella oleracea ... See more keywords
Voltage-Dependent Interaction of Capsaicine and Protons on TRPV1-Receptors
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DOI: 10.32607/20758251-2017-9-1-75-80
Abstract: The interaction of TRPV1-receptors agonists (capsaicin and protons) has been studied on cultured CHO cells transfected by TRPV1-receptors. Using the whole-cell patch-clamp approach, it was shown that summation of the currents induced by agonist application… read more here.
Keywords: currents induced; voltage dependent; trpv1 receptors; induced capsaicin ... See more keywords
Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19042387
Abstract: Humans have used opioids to suppress moderate to severe pain for thousands of years. However, the long-term use of opioids has several adverse effects, such as opioid tolerance, opioid-induced hyperalgesia, and addiction. In addition, the… read more here.
Keywords: side effects; opioid induced; trpv1 receptors; effects opioids ... See more keywords
Effects of Nitric Oxide on the Activity of P2X and TRPV1 Receptors in Rat Meningeal Afferents of the Trigeminal Nerve
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087519
Abstract: Nitric oxide is one of the endogenous molecules that play a key role in migraine. However, the interaction between NO and the main players in the nociceptive activity of the meningeal trigeminal afferents—TRPV1 and P2X3… read more here.
Keywords: trpv1 receptors; activity; nitric oxide; trigeminal nerve ... See more keywords