The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca2+‐LRMDA Axis in Myeloid Cells
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DOI: 10.1002/advs.202202857
Abstract: The transient receptor potential vanilloid 2 (TRPV2) channel is a nonselective cation channel that has been implicated in multiple sensory processes in the nervous system. Here, it is shown that TRPV2 in myeloid cells facilitates… read more here.
Keywords: trpv2; infection; myeloid cells; lrmda ... See more keywords
Rational Design and Validation of a Vanilloid-Sensitive TRPV2 Ion Channel
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DOI: 10.1016/j.bpj.2016.11.642
Abstract: Vanilloids activation of TRPV1 represents an excellent model system for ligand gating of ion channels. Recent studies using cryo electron microcopy (cryo-EM), computational analysis and functional quantification revealed the location of capsaicin-binding site and critical… read more here.
Keywords: trpv2; trpv2 quad; rational design; channel ... See more keywords
TRPV2 interacts with actin and reorganizes submembranous actin cytoskeleton
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20200118
Abstract: Abstract The understanding of molecules and their role in neurite initiation and/or extension is not only helpful to prevent different neurodegenerative diseases but also can be important in neuronal damage repair. In this work, we… read more here.
Keywords: trpv2; actin cytoskeleton; trpv2 interacts; actin reorganizes ... See more keywords
The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer science"
DOI: 10.1111/cas.15257
Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by accumulation of immature cells in bone marrow and peripheral blood. Although successful results were obtained with tyrosine kinase inhibitors, several patients show resistance. For this… read more here.
Keywords: myeloid leukemia; trpv2; effects cannabidiol; chronic myeloid ... See more keywords
Cannabidiol Inhibits Tumorigenesis in Cisplatin-Resistant Non-Small Cell Lung Cancer via TRPV2
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DOI: 10.3390/cancers14051181
Abstract: Simple Summary Drug resistance is the key factor contributing to the therapeutic failure of lung cancer and the deaths related to lung cancer. Our study demonstrated that small molecular weight non-psychotropic phytochemical, cannabidiol (CBD), inhibits… read more here.
Keywords: lung cancer; trpv2; cisplatin resistant; lung ... See more keywords
TRPV2: A Key Player in Myelination Disorders of the Central Nervous System
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DOI: 10.3390/ijms23073617
Abstract: Transient potential receptor vanilloid 2 (TRPV2) is widely expressed through the nervous system and specifically found in neuronal subpopulations and some glial cells. TRPV2 is known to be sensitized by methionine oxidation, which results from… read more here.
Keywords: player myelination; trpv2; myelination; key player ... See more keywords
Cannabidiol Enhances Microglial Beta-Amyloid Peptide Phagocytosis and Clearance via Vanilloid Family Type 2 Channel Activation
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DOI: 10.3390/ijms23105367
Abstract: Alzheimer’s disease (AD) is associated with the accumulation and aggregation of amyloid in the brain. The cation channel TRPV2 may mediate the pathological changes in mild cognitive impairment. A high-affinity agonist of TRPV2 named cannabidiol… read more here.
Keywords: trpv2; phagocytosis; cannabidiol enhances; phagocytosis clearance ... See more keywords
Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.78301
Abstract: Transient receptor potential vanilloid 2 (TRPV2) is a multimodal ion channel widely regulating central and peripheral functions. Its important involvement in immune responses has been suggested such as in the macrophages’ phagocytosis process. However, the… read more here.
Keywords: thermal sensitivity; trpv2; ion channel; tyrosine phosphorylation ... See more keywords