Acute inhibition of transient receptor potential vanilloid‐type 4 cation channel halts cytoskeletal dynamism in microglia
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24243
Abstract: Microglia, the resident macrophages of the central nervous system, are highly motile cells that support brain development, provision neuronal signaling, and protect brain cells against damage. Proper microglial functioning requires constant cell movement and morphological… read more here.
Keywords: inhibition; transient receptor; receptor potential; trpv4 ... See more keywords
Transient receptor potential vanilloid 4 activation inhibits the delayed rectifier potassium channels in hippocampal pyramidal neurons: An implication in pathological changes following pilocarpine‐induced status epilepticus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24749
Abstract: Activation of transient receptor potential vanilloid 4 (TRPV4) can increase hippocampal neuronal excitability. TRPV4 has been reported to be involved in the pathogenesis of epilepsy. Voltage‐gated potassium channels (VGPCs) play an important role in regulating… read more here.
Keywords: receptor potential; pyramidal neurons; hippocampal pyramidal; transient receptor ... See more keywords
Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis
Sign Up to like & getrecommendations! Published in 2021 at "STEM CELLS"
DOI: 10.1002/stem.3440
Abstract: Transient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium‐permeable cation channel that is highly expressed in cartilage and is sensitive to a variety of extracellular stimuli. The expression of this channel has been associated… read more here.
Keywords: receptor potential; chondrogenesis; transient receptor; trpv4 ... See more keywords
TRPV4: a Sensor for Homeostasis and Pathological Events in the CNS
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0998-8
Abstract: Transient receptor potential vanilloid type 4 (TRPV4) was originally described as a calcium-permeable nonselective cation channel. TRPV4 is now recognized as a polymodal ionotropic receptor: it is a broadly expressed, nonselective cation channel (permeable to… read more here.
Keywords: pathological events; homeostasis pathological; role; trpv4 ... See more keywords
Backbone NMR assignments of the extensive human and chicken TRPV4 N-terminal intrinsically disordered regions as important players in ion channel regulation
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecular Nmr Assignments"
DOI: 10.1007/s12104-022-10080-9
Abstract: Transient receptor potential (TRP) channels are important pharmacological targets due to their ability to act as sensory transducers on the organismic and cellular level, as polymodal signal integrators and because of their role in numerous… read more here.
Keywords: intrinsically disordered; regulation; trpv4; human chicken ... See more keywords
Transient receptor potential vanilloid 4 agonist GSK1016790A improves neurological outcomes after intracerebral hemorrhage in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.103
Abstract: Intracerebral hemorrhage (ICH) is one of the most severe subtypes of stroke with high morbidity and mortality. Although a lot of drug discovery studies have been conducted, the drugs with satisfactory therapeutic effects for motor… read more here.
Keywords: trpv4 agonist; agonist; intracerebral hemorrhage; receptor potential ... See more keywords
Novel gain-of-function mutation of TRPV4 associated with accelerated chondrogenic differentiation of dental pulp stem cells derived from a patient with metatropic dysplasia
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100648
Abstract: Metatropic dysplasia is a congenital skeletal dysplasia characterized by severe platyspondyly, dumbbell-like deformity of long tubular bones, and progressive kyphoscoliosis with growth. It is caused by mutations in the gene TRPV4, encoding the transient receptor… read more here.
Keywords: metatropic dysplasia; trpv4; dysplasia; stem ... See more keywords
Differential modulation of transendothelial electrical resistance by TRPV4 agonists is mediated by apoptosis and/or necrosis
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100672
Abstract: Transient receptor potential vanilloid 4 (TRPV4) has been implicated in many disease conditions also in the lung. Its activation leads to an increase endothelial permeability in an intracellular calcium-influx dependent manner. We investigated its function… read more here.
Keywords: trpv4 agonists; apoptosis; trpv4; transendothelial electrical ... See more keywords
Intravesical Activation of the Cation Channel TRPV4 Improves Bladder Function in a Rat Model for Detrusor Underactivity.
Sign Up to like & getrecommendations! Published in 2018 at "European urology"
DOI: 10.1016/j.eururo.2018.05.020
Abstract: BACKGROUND Improvement of bladder emptying by modulating afferent nerve activity is an attractive therapeutic strategy for detrusor underactivity. Transient receptor potential vanilloid 4 (TRPV4) is a sensory ion channel in urothelial cells that contribute to… read more here.
Keywords: detrusor; trpv4; rat model; bladder function ... See more keywords
Specific inhibition of TRPV4 enhances retinal ganglion cell survival in adult porcine retinal explants
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2016.11.002
Abstract: ABSTRACT Signaling through the polymodal cation channel Transient Receptor Potential Vanilloid 4 (TRPV4) has been implicated in retinal neuronal degeneration. To further outline the involvement of this channel in this process, we here explore modulation… read more here.
Keywords: cell survival; inhibition; adult porcine; trpv4 ... See more keywords
The role of TRPV4 in fibrosis.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.10.067
Abstract: The transient receptor potential vanilloid 4 (TRPV4) is a highly Ca2+-permeable non-selective cation channel in TRPV family. Accumulating evidence hints that TRPV4 play a significant role in a wide diversity of pathologic changes. Fibrosis is… read more here.
Keywords: trpv4; role trpv4; fibrosis; trpv4 fibrosis ... See more keywords