Transient receptor potential vanilloid 4 agonist GSK1016790A improves neurological outcomes after intracerebral hemorrhage in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.103
Abstract: Intracerebral hemorrhage (ICH) is one of the most severe subtypes of stroke with high morbidity and mortality. Although a lot of drug discovery studies have been conducted, the drugs with satisfactory therapeutic effects for motor… read more here.
Keywords: trpv4 agonist; agonist; intracerebral hemorrhage; receptor potential ... See more keywords
The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00006
Abstract: TRPV4 is a non-selective cation channel that tunes the function of different tissues including the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective and potent agonist of TRPV4 and a pharmacological tool that… read more here.
Keywords: trpv4 agonist; gsk1016790a regulates; trpv4 channels; trpv4 ... See more keywords