Simulated Microgravity Conditions Modulate Ca2+ Transport through TRPV4 Channels
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1371
Abstract: Astronauts in space tend to lose ten times as much bone mass each month as severe osteoporosis patients on Earth. Multiple reports on unloading-induced osteoporosis in bed-ridden patients indicate that bone mass correlates positively with… read more here.
Keywords: microgravity conditions; simulated microgravity; trpv4 channels; ca2 ... See more keywords
TRPV4 inhibition prevents paclitaxel-induced neurotoxicity in preclinical models
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.04.014
Abstract: ABSTRACT Paclitaxel is a cytotoxic drug which frequently causes sensory peripheral neuropathy in patients. Increasing evidence suggests that altered intracellular calcium (Ca2+) signals play an important role in the pathogenesis of this condition. In the… read more here.
Keywords: paclitaxel induced; trpv4 channels; neurotoxicity; ca2 ... See more keywords
Contribution of TRPV4 Channels in the Intrinsic Calcium Signaling Profiles of the Mouse Lung Microvascular Endothelium
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733755
Abstract: Endothelial calcium signaling in lung microvasculature is known to play an important role in maintaining lung endothelial barrier integrity. We previously characterized an intrinsic dynamic endothelial Ca2+ signaling pattern of the mouse lung microcirculation. Recently,… read more here.
Keywords: calcium; trpv4 channels; trpv4; physiology ... See more keywords
The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00006
Abstract: TRPV4 is a non-selective cation channel that tunes the function of different tissues including the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective and potent agonist of TRPV4 and a pharmacological tool that… read more here.
Keywords: trpv4 agonist; gsk1016790a regulates; trpv4 channels; trpv4 ... See more keywords
Astrocytic TRPV4 Channels and Their Role in Brain Ischemia
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087101
Abstract: Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-selective cation channels expressed in different cell types of the central nervous system. These channels can be activated by diverse physical and chemical stimuli,… read more here.
Keywords: astrocytic trpv4; ischemia; trpv4 channels; role ... See more keywords