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   Articles with "trpv4 channels" as a keyword



Simulated Microgravity Conditions Modulate Ca2+ Transport through TRPV4 Channels

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.1371

Abstract: Astronauts in space tend to lose ten times as much bone mass each month as severe osteoporosis patients on Earth. Multiple reports on unloading-induced osteoporosis in bed-ridden patients indicate that bone mass correlates positively with… read more here.

Keywords: microgravity conditions; simulated microgravity; trpv4 channels; ca2 ... See more keywords

TRPV4 inhibition prevents paclitaxel-induced neurotoxicity in preclinical models

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recommendations! Published in 2018 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2018.04.014

Abstract: ABSTRACT Paclitaxel is a cytotoxic drug which frequently causes sensory peripheral neuropathy in patients. Increasing evidence suggests that altered intracellular calcium (Ca2+) signals play an important role in the pathogenesis of this condition. In the… read more here.

Keywords: paclitaxel induced; trpv4 channels; neurotoxicity; ca2 ... See more keywords

Contribution of TRPV4 Channels in the Intrinsic Calcium Signaling Profiles of the Mouse Lung Microvascular Endothelium

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5733755

Abstract: Endothelial calcium signaling in lung microvasculature is known to play an important role in maintaining lung endothelial barrier integrity. We previously characterized an intrinsic dynamic endothelial Ca2+ signaling pattern of the mouse lung microcirculation. Recently,… read more here.

Keywords: calcium; trpv4 channels; trpv4; physiology ... See more keywords

Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels

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recommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atvbaha.124.322100

Abstract: BACKGROUND: Dysregulation of TRPV4 (transient receptor potential vanilloid type 4)–mediated signaling has been associated with inflammation and tissue fibrosis, both of which are key features in the pathophysiology of lymphatic system diseases; however, the expression… read more here.

Keywords: lymphatic vessel; lymphatic endothelial; trpv4 channels; trpv4 ... See more keywords

The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels

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recommendations! Published in 2019 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2019.00006

Abstract: TRPV4 is a non-selective cation channel that tunes the function of different tissues including the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective and potent agonist of TRPV4 and a pharmacological tool that… read more here.

Keywords: trpv4 agonist; gsk1016790a regulates; trpv4 channels; trpv4 ... See more keywords

Astrocytic TRPV4 Channels and Their Role in Brain Ischemia

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24087101

Abstract: Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-selective cation channels expressed in different cell types of the central nervous system. These channels can be activated by diverse physical and chemical stimuli,… read more here.

Keywords: astrocytic trpv4; ischemia; trpv4 channels; role ... See more keywords