The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.102
Abstract: TRPV5 is a Ca2+-selective channel that plays a key role in the reabsorption of Ca2+ ions in the kidney. Recently, a rare L530R variation (rs757494578) of TRPV5 was found to be associated with recurrent kidney… read more here.
Keywords: variation; associated recurrent; trpv5; structure ... See more keywords
A Gate Hinge Controls the Epithelial Calcium Channel TRPV5
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45489
Abstract: TRPV5 is unique within the large TRP channel family for displaying a high Ca2+ selectivity together with Ca2+-dependent inactivation. Our study aims to uncover novel insights into channel gating through in-depth structure-function analysis. We identify… read more here.
Keywords: gate hinge; hinge controls; controls epithelial; channel ... See more keywords
Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK‐II pathway
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15466
Abstract: Stimulation of calcium influx and suppression of autophagy play important roles in the pathogenesis of osteoarthritis (OA). In this study, we used a novel inhibitor of TRPV5 cation channels ‐ oxoglaucine to attenuate progression of… read more here.
Keywords: oxoglaucine mediates; osteoarthritis; mediates ca2; trpv5 ... See more keywords
Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000488725
Abstract: Background/Aims: Chondrocyte apoptosis is the most common pathological feature in cartilage in osteoarthritis (OA). Transient receptor potential channel vanilloid 5 (TRPV5) is important in regulating calcium ion (Ca2+) influx. Accumulating evidences suggest that Ca2+ is… read more here.
Keywords: chondrocyte apoptosis; trpv5; ca2; ca2 influx ... See more keywords