&Dgr;9‐tetrahydrocannabivarin impairs epithelial calcium transport through inhibition of TRPV5 and TRPV6
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.08.021
Abstract: ABSTRACT Compounds extracted from the cannabis plant, including the psychoactive &Dgr;9‐tetrahydrocannabinol (THC) and related phytocannabinoids, evoke multiple diverse biological actions as ligands of the G protein‐coupled cannabinoid receptors CB1 and CB2. In addition, there is… read more here.
Keywords: epithelial calcium; trpv5 trpv6; dgr;
Intracellular Helix-Loop-Helix Domain Modulates Inactivation Kinetics of Mammalian TRPV5 and TRPV6 Channels
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054470
Abstract: TRPV5 and TRPV6 are calcium-selective ion channels expressed at the apical membrane of epithelial cells. Important for systemic calcium (Ca2+) homeostasis, these channels are considered as gatekeepers of this cation transcellular transport. Intracellular Ca2+ exerts… read more here.
Keywords: inactivation kinetics; trpv6; helix; trpv5 trpv6 ... See more keywords