Depletion of TRRAP Induces p53‐Independent Senescence in Liver Cancer by Down‐Regulating Mitotic Genes
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30807
Abstract: Hepatocellular carcinoma (HCC) is an aggressive subtype of liver cancer with few effective treatments, and the underlying mechanisms that drive HCC pathogenesis remain poorly characterized. Identifying genes and pathways essential for HCC cell growth will… read more here.
Keywords: trrap; hcc cell; cancer; mitotic genes ... See more keywords
Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.01.010
Abstract: Acetylation of the lysine residues in histones and other DNA-binding proteins plays a major role in regulation of eukaryotic gene expression. This process is controlled by histone acetyltransferases (HATs/KATs) found in multiprotein complexes that are… read more here.
Keywords: missense variants; intellectual disability; trrap; missense ... See more keywords
Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Science"
DOI: 10.1111/cts.12988
Abstract: Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to reduce hepatosteatosis are needed. We performed a… read more here.
Keywords: metabolism; trrap; screen; lipid droplet ... See more keywords