Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms
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DOI: 10.1158/0008-5472.can-19-3607
Abstract: Truncated ASPP2 cooperates with E-cadherin and PTEN loss to drive breast cancer initiation and progression via two distinct mechanisms. ASPP2-induced actomyosin relaxation drives tumor initiation, while ASPP2-mediated YAP activation enhances tumor progression. Invasive lobular carcinoma… read more here.
Keywords: initiation; progression; initiation progression; loss ... See more keywords