Thioredoxin 1 is upregulated in the bone and bone marrow following experimental myocardial infarction: evidence for a remote organ response
Sign Up to like & getrecommendations! Published in 2020 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-020-01939-w
Abstract: Ischemia and reperfusion events, such as myocardial infarction (MI), are reported to induce remote organ damage severely compromising patient outcomes. Tissue survival and functional restoration relies on the activation of endogenous redox regulatory systems such… read more here.
Keywords: myocardial infarction; evidence; trx1; bone ... See more keywords
Berberine alleviates pulmonary hypertension through Trx1 and β-catenin signaling pathways in pulmonary artery smooth muscle cells.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111910
Abstract: Pulmonary arterial hypertension (PAH) is closely associated with profound vascular remodeling, especially pulmonary arterial medial hypertrophy and muscularization, due to aberrant proliferation of pulmonary artery smooth muscle cells (PASMCs). Berberine, a drug commonly used to… read more here.
Keywords: trx1 catenin; trx1; smooth muscle; artery smooth ... See more keywords
Thioredoxin-1 is required for the cardioprotecive effect of sildenafil against ischaemia/reperfusion injury and mitochondrial dysfunction in mice
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Research"
DOI: 10.1080/10715762.2019.1661404
Abstract: Abstract Sildenafil is a phosphodiesterase type 5 inhibitor which confers cardioprotection against myocardial ischaemia/reperfusion (I/R) injury. The aim of this study was to determine if Trx1 participates in cardioprotection exerted by sildenafil in an acute… read more here.
Keywords: trx1; reperfusion; effect; ischaemia ... See more keywords
The blood level of thioredoxin 1 as a supporting biomarker in the detection of breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "BMC Cancer"
DOI: 10.1186/s12885-021-09055-1
Abstract: Background There is a long-time unmet need for a means to detect breast cancer (BC) using blood. Although mammography is accepted as the gold standard for screening, a blood-based diagnostic can complement mammography and assist… read more here.
Keywords: cancer; sera; detection; level ... See more keywords
Thioredoxin 1 (TRX1) Overexpression Cancels the Slow Force Response (SFR) Development
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.622583
Abstract: The stretch of cardiac muscle increases developed force in two phases. The first phase occurs immediately after stretch and is the expression of the Frank–Starling mechanism, while the second one or slow force response (SFR)… read more here.
Keywords: overexpression; sfr development; trx1; force ... See more keywords
Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1063313
Abstract: Use of chimeric antigen receptor (CAR) T cells to treat B cell lymphoma and leukemia has been remarkably successful. Unfortunately, the therapeutic efficacy of CAR T cells against solid tumors is very limited, with immunosuppression… read more here.
Keywords: tumor; expression; car; pro oxidative ... See more keywords
β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10071153
Abstract: Thioredoxin 1 (Trx1) is a major antioxidant that acts adaptively to protect the heart during the development of diabetic cardiomyopathy. The molecular mechanism(s) responsible for regulating the Trx1 level and/or activity during diabetic cardiomyopathy is… read more here.
Keywords: ketone; trx1; ketone body; potentiates antioxidant ... See more keywords
Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Gastrointestinal Oncology"
DOI: 10.4251/wjgo.v11.i2.117
Abstract: BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer (CRC) onset that could improve clinical strategies. AIM To determine valid targets and a predictive biomarker's system of chronicization… read more here.
Keywords: redox immune; system; biomarker system; trx1 ... See more keywords