Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2021.107829
Abstract: In plant chloroplasts, thiol regulation is driven by two systems. One relies on the activity of thioredoxins through their light dependent reduction by ferredoxin via a ferredoxin-thioredoxin reductase (FTR). In the other system, a NADPH-dependent… read more here.
Keywords: thioredoxin reductase; reductase; trxr; domain ... See more keywords
Inhibition of thioredoxin reductase (TrxR) triggers oxidative stress-induced apoptosis in filarial nematode Setaria cervi channelized through ASK-1-p38 mediated caspase activation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2021.111364
Abstract: Inhibition of an imperative antioxidant enzyme with subsequent death is a victorious and widely accepted strategy to combat various infectious diseases. Among different antioxidant enzymes, thioredoxin reductase (TrxR) is an exclusive one. Studies have revealed… read more here.
Keywords: thioredoxin reductase; trxr; reductase trxr; apoptosis ... See more keywords
Selenium Atom-Polarization Effect Determines TrxR-Specific Recognition of Metallodrugs.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08802
Abstract: Thioredoxin reductase (TrxR) is highly overexpressed in cancer cells to promote malignant tumor survival. Designing drugs that inhibit TrxR activity is a promising approach to achieve highly effective cancer chemotherapy. However, the selectivity of TrxR… read more here.
Keywords: effect; trxr; polarization effect; center ... See more keywords
Clinical application of thioredoxin reductase as a novel biomarker in liver cancer
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85688-3
Abstract: Hepatic cancer is often amenable to surgery, including percutaneous ablation, trans-arterial chemoembolization. However, in metastatic cases, surgery is often not an effective option. Chemotherapy as a conventional clinical method for treatment of malignant diseases may… read more here.
Keywords: trxr; biomarker; application; cancer ... See more keywords
Plasma thioredoxin reductase: a potential diagnostic biomarker for gastric cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac052
Abstract: To improve the early detection of gastric cancer (GC), there is a growing need for novel and efficient biomarkers. We aimed to evaluate diagnostic value of thioredoxin reductase 1 (TXNRD1), which was found to be… read more here.
Keywords: thioredoxin reductase; trxr; gastric cancer;
Inhibition of Thioredoxin Reductase by Santamarine Conferring Anticancer Effect in HeLa Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.710676
Abstract: Natural products frequently have unique physiological activities and new action mechanisms due to their structural diversity and novelty, and are an important source for innovative drugs and lead compounds. We present herein that natural product… read more here.
Keywords: thioredoxin reductase; trxr; santamarine; inhibition thioredoxin ... See more keywords