Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics
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DOI: 10.3389/fphar.2021.774069
Abstract: Cruzain, the main cysteine protease of Trypanosoma cruzi, plays key roles in all stages of the parasite’s life cycle, including nutrition acquisition, differentiation, evasion of the host immune system, and invasion of host cells. Thus,… read more here.
Keywords: optimization trypanocidal; multiparameter optimization; activity; trypanocidal cruzain ... See more keywords