Application of a simple quantum chemical approach to ligand fragment scoring for Trypanosoma brucei pteridine reductase 1 inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-017-0035-4
Abstract: There is a need for improved and generally applicable scoring functions for fragment-based approaches to ligand design. Here, we evaluate the performance of a computationally efficient model for inhibitory activity estimation, which is composed only of multipole electrostatic… read more here.
Keywords: fragment; pteridine reductase; brucei pteridine; trypanosoma brucei ... See more keywords
Andrographolide induces oxidative stress-dependent cell death in unicellular protozoan parasite Trypanosoma brucei.
Sign Up to like & getrecommendations! Published in 2017 at "Acta tropica"
DOI: 10.1016/j.actatropica.2017.07.023
Abstract: African sleeping sickness is a parasitic disease in humans and livestock caused by Trypanosoma brucei throughout sub-Saharan Africa. Absence of appropriate vaccines and prevalence of drug resistance proclaim that a new way of therapeutic interventions… read more here.
Keywords: andro; trypanosoma brucei; trypanosoma; cell ... See more keywords
The conserved hypothetical protein Tb427.10.13790 is required for cytokinesis in Trypanosoma brucei.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.08.029
Abstract: Trypanosoma brucei, a flagellated protozoan causing the deadly tropical disease Human African Trypanosomiasis (HAT), affects people in sub-Saharan Africa. HAT therapy relies upon drugs which use is limited by toxicity and rigorous treatment regimes, while… read more here.
Keywords: protein; protein tb427; trypanosoma brucei; tb427 13790 ... See more keywords
C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113798
Abstract: Some pathogens, including parasites of the genus Trypanosoma causing Human and Animal African Trypanosomiases, cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation. Thus, their… read more here.
Keywords: nucleoside phosphonates; brucei adenine; trypanosoma brucei; adenosine monophosphate ... See more keywords
The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity
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DOI: 10.1016/j.isci.2020.101476
Abstract: Summary Human innate immunity to Trypanosoma brucei involves the trypanosome C-terminal kinesin TbKIFC1, which transports internalized trypanolytic factor apolipoprotein L1 (APOL1) within the parasite. We show that TbKIFC1 preferentially associates with cholesterol-containing membranes and is… read more here.
Keywords: surface; clearance; infectivity; trypanosoma brucei ... See more keywords
In vitro effects and mechanisms of action of Bidens pilosa in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2021.08.008
Abstract: Abstract Background and aim African trypanosomiasis poses serious health and economic concerns to humans and livestock in several sub-Saharan African countries. The aim of the present study was to identify the antitrypanosomal compounds from B. pilosa… read more here.
Keywords: vitro effects; effects mechanisms; mechanisms action; brucei ... See more keywords
The nuclear RNA binding protein RBP33 influences mRNA and spliced leader RNA abundance in Trypanosoma brucei.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2016.12.008
Abstract: RNA recognition motif (RRM) containing proteins are important regulators of gene expression in trypanosomes. Here we expand our current knowledge on the exclusively nuclear localized RRM domain containing protein RBP33 of Trypanosoma brucei. Overexpression of… read more here.
Keywords: spliced leader; rna; trypanosoma brucei; protein rbp33 ... See more keywords
Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2017.03.007
Abstract: Trypanosoma brucei, the agent of African Trypanosomiasis, is a flagellated protozoan parasite that develops in tsetse flies and in the blood of various mammals. The parasite acquires nutrients such as sugars, lipids and amino acids… read more here.
Keywords: trypanosoma brucei; methylglutaconyl coenzyme; mgcoa; coenzyme ... See more keywords
Temperature shift activates bloodstream VSG expression site promoters in Trypanosoma brucei.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2018.10.003
Abstract: Trypanosoma brucei relies on two types of variant surface glycoprotein (VSG) expression sites (ESs) for RNA polymerase I (Pol I) transcription of VSG pre-mRNA. Trypanosomes developing into infectious metacyclic cells in the tsetse vector use… read more here.
Keywords: bloodstream vsg; vsg; temperature; vsg expression ... See more keywords
A new reporter cell line for studies with proteasome inhibitors in Trypanosoma brucei.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2018.11.001
Abstract: A Trypanosoma brucei cell line is described that produces a visual readout of proteasome activity. The cell line contains an integrated transgene encoding an ubiquitin-green fluorescent protein (GFP) fusion polypeptide responsive to the addition of… read more here.
Keywords: trypanosoma brucei; proteasome inhibitors; cell line; line ... See more keywords
Induction of apoptosis in Trypanosoma brucei following endocytosis of ultra-small noble metal nanoclusters
Sign Up to like & getrecommendations! Published in 2021 at "Nano Today"
DOI: 10.1016/j.nantod.2021.101122
Abstract: Abstract Trypanosoma brucei, the causative agent of African trypanosomiasis, is a unicellular protozoan with an intricate life cycle involving an insect vector and mammalian hosts. Trypanosomiasis remains a threat to the health of human beings… read more here.
Keywords: endocytosis; trypanosoma brucei; metal nanoclusters; brucei ... See more keywords