Identification of Phenylpyrazolone Dimers as a New Class of Anti‐Trypanosoma cruzi Agents
Sign Up to like & getrecommendations! Published in 2019 at "Chemmedchem"
DOI: 10.1002/cmdc.201900370
Abstract: Chagas disease is becoming a worldwide problem; it is currently estimated that over six million people are infected. The two drugs in current use, benznidazole and nifurtimox, require long treatment regimens, show limited efficacy in… read more here.
Keywords: new class; dimers new; phenylpyrazolone dimers; identification phenylpyrazolone ... See more keywords
Frontline Science: Autophagy is a cell autonomous effector mechanism mediated by NLRP3 to control Trypanosoma cruzi infection
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.hi1118-461r
Abstract: Autophagy and inflammasome activation are cell‐autonomous and cross‐regulated processes involved in host resistance against infections. Our group previously described that NLRP3 inflammasome is required for the control of Trypanosoma cruzi, the causative agent of Chagas… read more here.
Keywords: effector mechanism; control trypanosoma; control; trypanosoma cruzi ... See more keywords
Metabolic Labeling of Surface Neo-sialylglyconjugates Catalyzed by Trypanosoma cruzi trans-Sialidase.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9148-8_10
Abstract: Trypanosoma cruzi, the protozoan agent of Chagas disease, has evolved an innovative metabolic pathway by which protective sialic acid (SA) residues are scavenged from host sialylglycoconjugates and transferred onto parasite surface mucin-like molecules (or surface… read more here.
Keywords: trans sialidase; surface; cruzi; metabolic labeling ... See more keywords
Homologous Expression of Glycosylphosphatidylinositol-Anchored Glycoproteins in Trypanosoma cruzi.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9148-8_9
Abstract: The surface coat of Trypanosoma cruzi is covered with glycosylphosphatidylinositol (GPI)-anchored glycoproteins (GAGPs) that contribute to parasite protection and to the establishment of a persistent infection in both the insect vector and the mammalian host.… read more here.
Keywords: anchored glycoproteins; glycosylphosphatidylinositol anchored; homologous expression; expression glycosylphosphatidylinositol ... See more keywords
Immune response triggered by Trypanosoma cruzi infection strikes adipose tissue homeostasis altering lipid storage, enzyme profile and adipokine expression
Sign Up to like & getrecommendations! Published in 2018 at "Medical Microbiology and Immunology"
DOI: 10.1007/s00430-018-0572-z
Abstract: Adipose tissue is a target of Trypanosoma cruzi infection being a parasite reservoir during the chronic phase in mice and humans. Previously, we reported that acute Trypanosoma cruzi infection in mice is linked to a… read more here.
Keywords: cruzi infection; trypanosoma cruzi; adipose tissue; tissue ... See more keywords
Oral infection of mice and host cell invasion by Trypanosoma cruzi strains from Mexico
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06254-5
Abstract: Oral infection by Trypanosoma cruzi has been responsible for frequent outbreaks of acute Chagas disease in the north of South America and in the Amazon region, where T. cruzi genetic group TcI predominates. TcI strains… read more here.
Keywords: infection mice; infection; host; oral infection ... See more keywords
Trypanosoma cruzi Importin α: ability to bind to a functional classical nuclear localization signal of the bipartite type.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology research"
DOI: 10.1007/s00436-020-06885-z
Abstract: Importin α, a transport factor in the classical pathway of nuclear transport of proteins in eukaryotes, has not been experimentally studied in trypanosomatids. A chimeric fluorescent version of this protein (TcImportin α-EGFP) expressed in transfected… read more here.
Keywords: nuclear localization; importin; ability; localization ... See more keywords
Metabolomics, lipidomics and proteomics profiling of myoblasts infected with Trypanosoma cruzi after treatment with different drugs against Chagas disease
Sign Up to like & getrecommendations! Published in 2019 at "Metabolomics"
DOI: 10.1007/s11306-019-1583-5
Abstract: Chagas disease, the most important parasitic infection in Latin America, is caused by the intracellular protozoan Trypanosoma cruzi. To treat this disease, only two nitroheterocyclic compounds with toxic side effects exist and frequent treatment failures… read more here.
Keywords: disease; drug; cruzi; host ... See more keywords
Mice Intragastric Infected with Insect and Blood Trypomastigotes of Trypanosoma cruzi IV: Differences and Similarities on the Evolution Profile and Response to Etiological Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Acta parasitologica"
DOI: 10.1007/s11686-021-00393-5
Abstract: PURPOSE Our goal was to analyze the outcome of infection and response to benznidazole (BZ) treatment in mice intragastrically inoculated with trypomastigotes forms of Trypanosoma cruzi from different origins. METHODS Twenty-four Swiss mice were divided in… read more here.
Keywords: etiological treatment; response; treatment; treatment mice ... See more keywords
Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2017.09.017
Abstract: The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs), TcI-TcVI and Tcbat. This article reviews the present… read more here.
Keywords: genetic diversity; something; cruzi; trypanosoma cruzi ... See more keywords
Differential infectivity of two Trypanosoma cruzi strains in placental cells and tissue.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.07.001
Abstract: Congenital Chagas disease, caused by Trypanosoma cruzi (T. cruzi), has become epidemiologically relevant. The probability of congenital transmission depends on the maternal and developing fetal/newborn immune responses, placental factors and importantly, the virulence of the… read more here.
Keywords: differential infectivity; infectivity two; cruzi; trypanosoma cruzi ... See more keywords