Oligopeptidase B, a missing enzyme in mammals and a potential drug target for trypanosomatid diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Biochimie"
DOI: 10.1016/j.biochi.2019.10.006
Abstract: Oligopeptidases B (OPB) belong to the S9 prolyl oligopeptidase family and are expressed in prokaryotes, some eukaryotes and in some higher plants. OPB is not found in any of the mammalian genomes available to date.… read more here.
Keywords: mammals potential; oligopeptidase missing; target; missing enzyme ... See more keywords
Aminoacyl tRNA Synthetases: Implications of Structural Biology in Drug Development against Trypanosomatid Parasites
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00826
Abstract: The ensemble of aminoacyl tRNA synthetases is regarded as a key component of the protein translation machinery. With the progressive increase in structure-based studies on tRNA synthetase-ligand complexes, the detailed picture of these enzymes is… read more here.
Keywords: structural biology; trypanosomatid; development; trna synthetases ... See more keywords
TrypsNetDB: An integrated framework for the functional characterization of trypanosomatid proteins
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005368
Abstract: Trypanosomatid parasites cause serious infections in humans and production losses in livestock. Due to the high divergence from other eukaryotes, such as humans and model organisms, the functional roles of many trypanosomatid proteins cannot be… read more here.
Keywords: integrated framework; trypanosomatid proteins; trypanosomatid parasites; framework functional ... See more keywords