Factors influencing passive surveillance for T. b. rhodesiense human african trypanosomiasis in Uganda.
Sign Up to like & getrecommendations! Published in 2017 at "Acta tropica"
DOI: 10.1016/j.actatropica.2016.05.009
Abstract: INTRODUCTION Sleeping sickness or Human African Trypanosomiasis (HAT) is a neglected tropical disease of public health importance across much of Sub-Saharan Africa. In Uganda, chronic T. b. gambiense HAT (gHAT) and acute T. b. rhodesiense… read more here.
Keywords: trypanosomiasis; staff; surveillance; human african ... See more keywords
Experiences of the one-health approach by the Uganda Trypanosomiasis Control Council and its secretariat in the control of zoonotic sleeping sickness in Uganda
Sign Up to like & getrecommendations! Published in 2020 at "Parasite Epidemiology and Control"
DOI: 10.1016/j.parepi.2020.e00185
Abstract: Elimination of sleeping sickness from endemic countries like Uganda is key if the affected communities are to exploit the potential of the available human and livestock resources (production and productivity). Trypanosoma brucei rhodesiense, the parasite… read more here.
Keywords: trypanosomiasis; zoonotic sleeping; control; one health ... See more keywords
Melarsoprol Resistance in African Trypanosomiasis.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in parasitology"
DOI: 10.1016/j.pt.2018.04.002
Abstract: Arsenicals were introduced as monotherapies for the treatment of human African trypanosomiasis, or sleeping sickness, over 100 years ago. Toxicity has always been an issue but these drugs have proven to be both effective and… read more here.
Keywords: trypanosomiasis; drug; african trypanosomiasis; melarsoprol resistance ... See more keywords
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c02104
Abstract: African animal trypanosomiasis or nagana, caused principally by infection of the protozoan parasites Trypanosoma congolense and Trypanosoma vivax, is a major problem in cattle and other livestocks in sub-Saharan Africa. Current treatments are threatened by… read more here.
Keywords: african animal; chemistry; cyclin dependent; trypanosomiasis ... See more keywords
A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of travel medicine"
DOI: 10.1093/jtm/tay024
Abstract: We present a case of East-African trypanosomiasis (EAT) in a 56-year-old Dutch woman returning from holiday in Tanzania and Kenya. The diagnosis was delayed due to the lack of suspicion and secondly because of postponed… read more here.
Keywords: trypanosomiasis; diagnosis; case; african trypanosomiasis ... See more keywords
Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007189
Abstract: Human and animal African trypanosomiasis (HAT & AAT, respectively) remain a significant health and economic issue across much of sub-Saharan Africa. Effective control of AAT and potential eradication of HAT requires affordable, sensitive and specific… read more here.
Keywords: small rna; trypanosomiasis; detection; microscopy ... See more keywords
Breeding of African sheep reared under low-input/output smallholder production systems for trypanotolerance
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary World"
DOI: 10.14202/vetworld.2022.1031-1043
Abstract: Trypanosomiasis is a disease caused by unicellular protozoan parasites. Small ruminants succumb to trypanosomiasis in areas of high tsetse fly challenge, resulting in serious economic loss often to farmers in low-input smallholder systems. At present,… read more here.
Keywords: trypanosomiasis; low input; production; smallholder ... See more keywords
Molecular genotyping reveals mixed bovine and human trypanosomiasis in cattle from West Africa
Sign Up to like & getrecommendations! Published in 2023 at "Veterinary World"
DOI: 10.14202/vetworld.2023.149-153
Abstract: Background and Aim: Animal trypanosomiasis is a major contributor to agricultural and economic losses, especially in sub-Saharan Africa. We have shown that some animal species expressed genes that are significant players in immune response to… read more here.
Keywords: molecular genotyping; trypanosome species; mixed bovine; trypanosomiasis ... See more keywords
Methods applied to the Diagnosis of Cattle Trypanosoma Vivax Infection: An Overview of the Current State of The Art.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666221108101446
Abstract: Trypanosoma vivax bovine trypanosomiasis is a relevant disease in domestic ungulates in Latin America causing different types of livestock losses, particularly in African and South American countries, leading to loss of millions of dollars/year related… read more here.
Keywords: diagnosis; state art; trypanosomiasis; trypanosoma vivax ... See more keywords
Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043144
Abstract: African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan Africa. Treatment options are very limited and threatened by resistance. Tubercidin (7-deazaadenosine) analogs… read more here.
Keywords: vivax; nucleoside transporters; trypanosomiasis; congolense ... See more keywords
The History of the ABC Proteins in Human Trypanosomiasis Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11090988
Abstract: Human trypanosomiasis affects nearly eight million people worldwide, causing great economic and social impact, mainly in endemic areas. T. cruzi and T. brucei are protozoan parasites that present efficient mechanisms of immune system evasion, leading… read more here.
Keywords: history; abc transporters; human trypanosomiasis; trypanosomiasis ... See more keywords