Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2016.1250755
Abstract: Abstract The study presented here aimed at identifying a new class of compounds acting against Leishmania parasites, the causative agent of Leishmaniasis. For this purpose, the thioether derivatives of our in-house library have been evaluated… read more here.
Keywords: trypanothione; inhibition leishmania; leishmania infantum; trypanothione reductase ... See more keywords
Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.900882
Abstract: Trypanothione reductase (TR) is a key factor in the redox homeostasis of trypanosomatid parasites, critical for survival in the hostile oxidative environment generated by the host to fight infection. TR is considered an attractive target… read more here.
Keywords: design; site; trypanothione; target ... See more keywords