Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies
Sign Up to like & getrecommendations! Published in 2017 at "Peptide Science"
DOI: 10.1002/bip.22927
Abstract: Cyclotides are plant‐derived host defense peptides displaying exceptional stability due to their cyclic cystine knot comprising three intertwined disulfide bonds and a cyclic backbone. Their six conserved cysteine residues are separated by backbone loops with… read more here.
Keywords: chimeric; cyclotides bius; trypsin inhibitor; bius trypsin ... See more keywords
Spliced analogues of trypsin inhibitor SFTI‐1 and their application for tracing proteolysis and delivery of cargos inside the cells
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DOI: 10.1002/bip.22988
Abstract: A series of analogues of trypsin inhibitor SFTI‐1 were designed and synthesized to monitor peptide splicing. In the middle part of the SFTI‐1 analogues, which is released upon incubation with proteinase, the RGD sequence or… read more here.
Keywords: spliced analogues; trypsin inhibitor; peptide splicing; analogues trypsin ... See more keywords
Inter‐alpha‐trypsin inhibitor heavy chain 4: A serologic marker relating to disease risk, activity, and treatment outcomes of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24231
Abstract: Inter‐alpha‐trypsin inhibitor heavy chain 4 (ITIH4) regulates immunity and inflammation, but its clinical role in rheumatoid arthritis (RA) patients remains unclear. Hence, this study was conducted to explore the association of circulating ITIH4 with disease… read more here.
Keywords: heavy chain; inter alpha; alpha trypsin; trypsin inhibitor ... See more keywords
Longitudinal change of serum inter‐alpha‐trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24834
Abstract: Inter‐alpha‐trypsin inhibitor heavy chain H4 (ITIH4) inhibits infection‐induced inflammation and multiorgan injury through several methods. The present study aimed to estimate the association of serum ITIH4 with inflammatory cytokines, multiorgan injury, and death risk in… read more here.
Keywords: heavy chain; inter alpha; alpha trypsin; trypsin inhibitor ... See more keywords
First insights into insecticidal activity against Aedes aegypti and partial biochemical characterization of a novel low molecular mass chymotrypsin-trypsin inhibitor purified from Lonchocarpus sericeus seeds.
Sign Up to like & getrecommendations! Published in 2018 at "Pest management science"
DOI: 10.1002/ps.4812
Abstract: BACKGROUND Arboviroses such as dengue, Zika and chikungunya represent a serious public health issue as a consequence of the absence of approved vaccines or specific antiviral drugs against the arboviruses that cause them. One way… read more here.
Keywords: aedes aegypti; inhibitor; mass; chymotrypsin ... See more keywords
Trypsin inhibitor from Enterolobium contortisiliquum seeds impairs Aedes aegypti development and enhances the activity of Bacillus thuringiensis toxins.
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.5918
Abstract: BACKGROUND Disease vector insects are barriers for human development. The use of synthetic chemicals to control these vectors has caused damage to the environment and contributed to arising of resistant insect populations. This has led… read more here.
Keywords: enterolobium contortisiliquum; thuringiensis toxins; trypsin inhibitor; activity ... See more keywords
Quantitative proteomic analyses reveal that RBBI3.3, a trypsin inhibitor protein, plays an important role in Magnaporthe oryzae infection in rice
Sign Up to like & getrecommendations! Published in 2018 at "Plant Growth Regulation"
DOI: 10.1007/s10725-018-0435-z
Abstract: Magnaporthe oryzae (M. oryzae) is the causative agent of rice blast, the most destructive rice disease in China. This study was designed to ascertain the molecular mechanisms of the response of rice to M. oryzae… read more here.
Keywords: quantitative proteomic; rice; magnaporthe oryzae; trypsin inhibitor ... See more keywords
Recombinant buckwheat trypsin inhibitor decreases fat accumulation via the IIS pathway in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.110753
Abstract: Buckwheat trypsin inhibitor (BTI) is a low molecular weight polypeptide that can help to prevent metabolic diseases such as obesity, hyperglycemia and hyperlipidemia. Herein, the effects of recombinant BTI (rBTI) on fat accumulation in Caenorhabditis… read more here.
Keywords: rbti; accumulation; fat accumulation; buckwheat trypsin ... See more keywords
Analysis of Kunitz inhibitors from plants for comprehensive structural and functional insights.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.02.148
Abstract: Legume Kunitz type trypsin inhibitor (KTI) family is one of the most versatile families of proteins. A typical KTI features a single peptide folded in β-trefoil manner, with the molecular weight about 20-22kDa and two… read more here.
Keywords: kunitz; inhibitors plants; trypsin inhibitor; kunitz inhibitors ... See more keywords
Characterization of a Kunitz trypsin inhibitor from Enterolobium timbouva with activity against Candida species.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.07.034
Abstract: Scientific advances have not been sufficient to accompany the growing resistance to antimicrobial medicines. High mortality rates due to opportunistic infections have threated human health. The development of new drugs, such as those obtained from… read more here.
Keywords: inhibitor enterolobium; enterolobium timbouva; activity candida; trypsin inhibitor ... See more keywords
A trypsin inhibitor-like protein secreted by Cotesia vestalis teratocytes inhibits hemolymph prophenoloxidase activation of Plutella xylostella.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of insect physiology"
DOI: 10.1016/j.jinsphys.2019.04.009
Abstract: To establish successful infections, endoparasitoid wasps must develop strategies to evade immune responses of the host. Here, we identified and characterized a teratocytes-expressed gene encoding a trypsin inhibitor-like protein containing a cysteine-rich domain from Cotesia… read more here.
Keywords: inhibitor like; like protein; trypsin inhibitor; cotesia vestalis ... See more keywords