Development of mutant human immunoreactive trypsinogen 1 (IRT1) and mutant human immunoreactive trypsinogen 2 (IRT2) for use in immunoassays.
Sign Up to like & getrecommendations! Published in 2020 at "Protein expression and purification"
DOI: 10.1016/j.pep.2020.105572
Abstract: Immunoreactive Trypsinogen (IRT) is a protein-based pancreatic proenzyme that has an important role in protein digestion in humans. In human body, once IRT present in the small intestine, the proteolytic cleavage activates trypsinogen into trypsin.… read more here.
Keywords: immunoreactive trypsinogen; human immunoreactive; mutant human; trypsinogen irt1 ... See more keywords
Effects of tRNA-derived fragments and microRNAs regulatory network on pancreatic acinar intracellular trypsinogen activation
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2018880
Abstract: ABSTRACT Acute pancreatitis (AP) is a common gastrointestinal disease with substantial morbidity and mortality. Pancreatic acinar intracellular trypsinogen activation (PAITA) is an important event in the early stage of AP. The present study aimed to… read more here.
Keywords: trypsinogen; acinar intracellular; pancreatic acinar; trypsinogen activation ... See more keywords
Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines
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DOI: 10.3389/fcimb.2018.00091
Abstract: Cleavage and activation of hemagglutinin (HA) by trypsin-like proteases in influenza A virus (IAV) are essential prerequisites for its successful infection and spread. In host cells, some transmembrane serine proteases such as TMPRSS2, TMPRSS4 and… read more here.
Keywords: cell lines; infection; human cell; enterokinase ... See more keywords
The Rabep1-Mediated Endocytosis and Activation of Trypsinogen to Promote Pancreatic Stellate Cell Activation
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DOI: 10.3390/biom12081063
Abstract: Background: The pathogenesis of chronic pancreatitis is still unclear. Trypsinogen activation is an active factor in acute pancreatitis that has not been studied in the occurrence of chronic pancreatitis. Methods: Immunofluorescence was used to detect… read more here.
Keywords: pancreatic stellate; trypsinogen; activation trypsinogen; endocytosis ... See more keywords