An integrated molecular modeling approach for the tryptase monomer–curcuminoid recognition analysis: conformational and bioenergetic features
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-018-9777-5
Abstract: Human mast cell tryptase has been shown as an activating enzyme in matrix degradation process. The previous study suggest that tryptase either alone or in joining with activation of metalloproteinases, can associate in extra cellular… read more here.
Keywords: tryptase; analysis; tryptase monomer; integrated molecular ... See more keywords
Co- localization of Flt1 and tryptase of mast cells in skin wound of rats with type I diabetes: Initial studies.
Sign Up to like & getrecommendations! Published in 2021 at "Acta histochemica"
DOI: 10.1016/j.acthis.2021.151680
Abstract: Random skin flap (RSF) is commonly used in plastic and reconstructive surgery, but its distal part often occurs ischemia. Type 1 Diabetes mellitus (T1DM), may be detrimental for flap survival by provide sever ischemia. We… read more here.
Keywords: tryptase; mast cells; mast; type diabetes ... See more keywords
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.009
Abstract: Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and represent an unmet need. We show that mast cell tryptase is elevated in severe asthma patients… read more here.
Keywords: severe asthma; tryptase; tryptase antibody; anti tryptase ... See more keywords
Post mortem tryptase cut-off level for anaphylactic death.
Sign Up to like & getrecommendations! Published in 2018 at "Forensic science international"
DOI: 10.1016/j.forsciint.2017.12.035
Abstract: Serum mast cell tryptase is used to support the diagnosis of anaphylaxis. The recommended clinical cut-off for total tryptase ( read more here.
Keywords: tryptase; anaphylactic death; mortem tryptase; post mortem ... See more keywords
Hereditary alpha-tryptasemia
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000849
Abstract: Purpose of review To discuss our evolving knowledge about the genetic variations in human tryptase and recent advances in associated clinical phenotypes. Recent findings Hereditary alpha-tryptasemia (HAT) is an autosomal dominant genetic trait and a… read more here.
Keywords: alpha tryptasemia; physiology; tryptase; hereditary alpha ... See more keywords
Postmortem Serum Tryptase Levels with Special Regard to Acute Cardiac Deaths
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.13420
Abstract: An elevated serum tryptase concentration is considered a specific marker for systemic mast cell activation, a central feature of anaphylaxis. However, in some cases of acute cardiovascular death, high concentrations of serum tryptase are also… read more here.
Keywords: tryptase; group; postmortem serum; cardiac deaths ... See more keywords
Serum tryptase levels in patients with psoriasis: a pilot study for a possible useful biomarker.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and experimental dermatology"
DOI: 10.1111/ced.14874
Abstract: In psoriasis, biomarkers for disease prognosis and response to treatment may help clinicians in order to improve patient management.1 Although many efforts have been made to identify psoriasis biomarkers (such as CRP, cytochrome-c, haptoglobin, platelet… read more here.
Keywords: tryptase; levels patients; tryptase levels; psoriasis ... See more keywords
A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Science"
DOI: 10.1111/cts.13483
Abstract: Tryptase, a protease implicated in asthma pathology, is secreted from mast cells upon activation during an inflammatory allergic response. MTPS9579A is a novel monoclonal antibody that inhibits tryptase activity by irreversibly dissociating the active tetramer… read more here.
Keywords: moderate severe; tryptase; model; severe asthma ... See more keywords
Elevated Serum Tryptase in Non-Anaphylaxis Cases: A Concise Review
Sign Up to like & getrecommendations! Published in 2020 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000506199
Abstract: One of the most important blood tests in the field of allergy, mast cell tryptase has numerous diagnostic uses, particularly for anaphylactic reactions and for the diagnosis of mastocytosis. However, there are numerous other non-anaphylactic… read more here.
Keywords: tryptase; anaphylaxis cases; non anaphylaxis; tryptase non ... See more keywords
Mast Cell Tryptase Potentiates Neutrophil Extracellular Trap Formation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of innate immunity"
DOI: 10.1159/000520972
Abstract: Previous research has indicated an intimate functional communication between mast cells (MCs) and neutrophils during inflammatory conditions, but the nature of such communication is not fully understood. Activated neutrophils are known to release DNA-containing extracellular… read more here.
Keywords: dna; net formation; tryptase; mast ... See more keywords
Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020006157
Abstract: Mastocytosis is a hematopoietic neoplasm characterized by expansion of KIT D816V-mutated clonal mast cells in various organs and severe or even life-threatening anaphylactic reactions. Recently, hereditary α-tryptasemia (HαT) has been described as a common genetic… read more here.
Keywords: tryptase; mediator related; tryptasemia; related symptoms ... See more keywords