A Ferrocene-Tryptophan Conjugate: The Role of the Indolic Nitrogen in Supramolecular Assembly.
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DOI: 10.1002/cplu.201700407
Abstract: Bio-organometallic ferrocene-containing amino acids and peptides have been reported to form gels and are interesting to study due to their structural properties and applications for biological purposes. In this study, a ferrocene-dicarboxylic acid derivative of… read more here.
Keywords: indolic nitrogen; tryptophan; tryptophan conjugate; ferrocene tryptophan ... See more keywords
Chromatographic analysis of tryptophan metabolites
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DOI: 10.1002/jssc.201700184
Abstract: The kynurenine pathway generates multiple tryptophan metabolites called collectively kynurenines and leads to formation of the enzyme cofactor nicotinamide adenine dinucleotide. The first step in this pathway is tryptophan degradation, initiated by the rate‐limiting enzymes… read more here.
Keywords: analysis tryptophan; chromatographic analysis; tryptophan metabolites; tryptophan ... See more keywords
Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation
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DOI: 10.1002/med.21752
Abstract: In a complex, diverse intestinal environment, commensal microbiota metabolizes excessive dietary tryptophan to produce more bioactive metabolites connecting with kinds of diverse process, such as host physiological defense, homeostasis, excessive immune activation and the progression… read more here.
Keywords: immunity; microbiota; mucosal immunity; intestinal mucosal ... See more keywords
Enrichment and characterization of a bacterial mixture capable of utilizing C-mannosyl tryptophan as a carbon source
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DOI: 10.1007/s10719-017-9807-2
Abstract: C-Mannosylation, a protein-modification found in various eukaryotes, involves the attachment of a single mannose molecule to selected tryptophan residues of proteins. Since C-mannosyl tryptophan (CMW) was detected in human urine, it is generally thought that… read more here.
Keywords: carbon source; cmw; mannosyl tryptophan; tryptophan ... See more keywords
Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy
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DOI: 10.1007/s11255-017-1596-9
Abstract: PurposeHypoxia plays a significant role in the pathogenesis of acute kidney injury (AKI). Autophagy protects from AKI. Amino acid deprivation induces autophagy. The effect of l-tryptophan depletion on survival and autophagy in cultures of renal… read more here.
Keywords: renal proximal; without tryptophan; tryptophan; autophagy ... See more keywords
Purification and characterization of Stenotrophomonas maltophilia-derived l-amino acid ester hydrolase for synthesizing dipeptide, isoleucyl-tryptophan
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DOI: 10.1007/s13205-018-1195-1
Abstract: In the present study, we purified α-amino acid ester hydrolase (AEH) from cell-free extracts of the Stenotrophomonas maltophilia strain HS1. The approximately 70-kDa AEH from S. maltophilia HS1 (SmAEH) was homogeneous in sodium dodecyl sulphate… read more here.
Keywords: acid ester; amino acid; isoleucyl; tryptophan ... See more keywords
Tryptophan metabolism and its relationship with central nervous system toxicity in people living with HIV switching from efavirenz to dolutegravir
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DOI: 10.1007/s13365-018-0688-3
Abstract: The mechanisms underlying central nervous system (CNS) toxicities in antiretroviral-treated persons living with HIV (PLWH) remain elusive. We investigated the associations between markers of tryptophan metabolism and measurements of CNS toxicity in PLWH. In a… read more here.
Keywords: nervous system; central nervous; tryptophan; toxicity ... See more keywords
Tryptophan circuit in fatigue: From blood to brain and cognition
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DOI: 10.1016/j.brainres.2017.09.002
Abstract: Brain tryptophan and its neuroactive metabolites play key roles in central fatigue. However, previous brain function analysis targets may have included both glia and neurons together. Here, we clarified the fatigue-cognitive circuit of the central-peripheral… read more here.
Keywords: kynurenic acid; fatigue; tryptophan; circuit ... See more keywords
Removing the by-products acetic acid and NH4+ from the l-tryptophan broth by vacuum thin film evaporation during l-tryptophan production
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DOI: 10.1016/j.ejbt.2018.04.003
Abstract: Background: During L-tryptophan production by Escherichia coli, the by-products, acetic acid and NH4 +, accumulate in the fermentation broth, resulting in inhibited cell growth and activity and decreased L-tryptophan production. To improve the L-tryptophan yield… read more here.
Keywords: production; acid nh4; tryptophan; vacuum ... See more keywords
Kinetic evaluation of the formation of tryptophan derivatives in the kynurenine pathway during wort fermentation using Saccharomyces pastorianus and Saccharomyces cerevisiae.
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DOI: 10.1016/j.foodchem.2019.124975
Abstract: This study aimed to evaluate the formation of tryptophan derivatives in the kynurenine pathway during wort fermentation using a multi-response kinetic model and an empirical modified logistic model. Saccharomyces cerevisiae NCYC 88 (ale yeast) and… read more here.
Keywords: fermentation; tryptophan derivatives; tryptophan; formation ... See more keywords
Enrichment of cellulose acetate nanofibre assemblies for therapeutic delivery of l-tryptophan.
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DOI: 10.1016/j.ijbiomac.2017.11.124
Abstract: The essential amino acid l-tryptophan is naturally present in the body, and is also available as a water soluble dietary supplement. The feasibility of preparing enriched cellulose acetate (CA)-based fibres as a vehicle for therapeutic… read more here.
Keywords: delivery; therapeutic delivery; tryptophan; enrichment cellulose ... See more keywords