Tryptophan Hydroxylase 2 Knockout Male Rats Exhibit a Strengthened Oxytocin System, Are Aggressive, and Are Less Anxious
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00448
Abstract: The central serotoninergic system is critical for stress responsivity and social behavior, and its dysregulations have been centrally implicated in virtually all neuropsychiatric disorders. Genetic serotonin depletion animal models could provide a tool to elucidate… read more here.
Keywords: system; male rats; tryptophan hydroxylase; oxytocin system ... See more keywords
Tryptophan hydroxylase 2 as a therapeutic target for psychiatric disorders: focus on animal models
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1634691
Abstract: ABSTRACT Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 gene are associated with psychiatric disorders. Area covered: This review… read more here.
Keywords: psychiatric disorders; tryptophan hydroxylase; tph2 activity; tph2 ... See more keywords
TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients
Sign Up to like & getrecommendations! Published in 2021 at "BMC Gastroenterology"
DOI: 10.1186/s12876-021-02012-z
Abstract: Background The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin… read more here.
Keywords: acute pancreatitis; pancreatitis; rs211105; serotonin ... See more keywords
In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0229730
Abstract: The tryptophan hydroxylase 2 (TPH2) enzyme catalyzes the first step of serotonin biosynthesis. Serotonin is known for its role in several homeostatic systems related to sleep, mood, and food intake. As the reaction catalyzed by… read more here.
Keywords: protein; analysis; psychiatric disorders; tryptophan hydroxylase ... See more keywords
Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.907437
Abstract: Human tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the synthesis of serotonin. Its dysfunction has been implicated in various psychiatric disorders such as depression, autism, and bipolar disorder. TPH2 is typically decreased in… read more here.
Keywords: human tryptophan; cryo structure; structure; tph2 ... See more keywords
Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054862
Abstract: The monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has important functions both in the neural system and during embryonic development in mammals. In this study, we set out to investigate whether and how endogenous serotonin affects reprogramming… read more here.
Keywords: serotonin biosynthesis; pluripotent state; tryptophan hydroxylase;
Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomedical Research"
DOI: 10.7555/jbr.31.20170026
Abstract: Unbalanced brain serotonin (5-HT) levels have implications in various behavioral abnormalities and neuropsychiatric disorders. The biosynthesis of neuronal 5-HT is regulated by the rate-limiting enzyme, tryptophan hydroxylase-2 (TPH2). In the present study, the clustered regularly… read more here.
Keywords: hydroxylase gene; generation tryptophan; crispr cas9; tryptophan hydroxylase ... See more keywords