Circulating tryptophan–kynurenine pathway metabolites are associated with all‐cause mortality among patients with stage I–III colorectal cancer
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Cancer"
DOI: 10.1002/ijc.35183
Abstract: Alterations within the tryptophan–kynurenine metabolic pathway have been linked to the etiology of colorectal cancer (CRC), but the relevance of this pathway for prognostic outcomes in CRC patients needs further elucidation. Therefore, we investigated associations… read more here.
Keywords: pathway metabolites; cause mortality; tryptophan kynurenine; kynurenine pathway ... See more keywords
Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites
Sign Up to like & getrecommendations! Published in 2022 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2022.103917
Abstract: Summary Background Neuroinflammatory diseases such as encephalitis, meningitis, multiple sclerosis and other neurological diseases with inflammatory components, have demonstrated a need for diagnostic biomarkers to define treatable and reversible neuroinflammation. The development and clinical validation… read more here.
Keywords: inflammation panel; encephalitis; acid; inflammation ... See more keywords
Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2018.01.014
Abstract: BACKGROUND Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in… read more here.
Keywords: tryptophan kynurenine; mdd; first episode; episode drug ... See more keywords
Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams
Sign Up to like & getrecommendations! Published in 2021 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2021.105273
Abstract: Perinatal depression (PND) affects 15% of mothers. Selective serotonin reuptake inhibitors (SSRIs) are currently the first-line of treatment for PND but are not always efficacious. Previously, we found significant reductions in plasma tryptophan concentrations and… read more here.
Keywords: tryptophan kynurenine; flx; treatment; efficacy ... See more keywords
Sacubitril/valsartan ameliorates cardiac function and ventricular remodeling in CHF rats via the inhibition of the tryptophan/kynurenine metabolism and inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-62472-7
Abstract: Sacubitril/valsartan has been highly recognized as a treatment for Chronic heart failure (CHF). Its potential cardioprotective benefits and mechanisms, however, remain to be explored. Metabolomics can be used to identify the metabolic characteristics and related… read more here.
Keywords: chf rats; sacubitril valsartan; tryptophan kynurenine; kynurenine metabolism ... See more keywords
Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2022.2040050
Abstract: Abstract Tryptophan metabolism in the tumor microenvironment exerts immunosuppressive effects by affecting the anti-tumor functions of immune cells. The immunosuppressive roles of tryptophan and tryptophan metabolites and their effects on the FOXP3 gene, highly expressed… read more here.
Keywords: tryptophan kynurenine; level; expression; foxp3 gene ... See more keywords
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02175-2
Abstract: Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools. IBD is strongly associated… read more here.
Keywords: depression; bowel disease; tryptophan kynurenine; inflammatory bowel ... See more keywords
7286 Higher Order Associations Linking Tryptophan, Kynurenine, And Tyrosine As Serum Markers Of Glucocorticoid Downstream Action In Adipose Tissue
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.201
Abstract: Abstract Disclosure: K. Bennett: None. T. Garner: None. D. Chantzichristos: Speaker; Self; Sanofi, Takeda. P. Jansson: None. A. Stevens: None. G. Johannsson: Consulting Fee; Self; Novo Nordisk, Shire, AstraZeneca. Speaker; Self; Novo Nordisk, Pfizer, Inc..… read more here.
Keywords: tryptophan kynurenine; serum; tissue; action ... See more keywords
Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0192169
Abstract: Objective Obesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio (KTR). We investigated circulating tryptophan, kynurenine and… read more here.
Keywords: surgery; tryptophan kynurenine; bariatric surgery; kynurenine pathway ... See more keywords
Tryptophan and Kynurenine Enhances the Stemness and Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2021 at "Materials"
DOI: 10.3390/ma14010208
Abstract: Aging tissues present a progressive decline in homeostasis and regenerative capacities, which has been associated with degenerative changes in tissue-specific stem cells and stem cell niches. We hypothesized that amino acids could regulate the stem… read more here.
Keywords: tryptophan kynurenine; vivo; bone; differentiation ... See more keywords
The Tryptophan/Kynurenine Pathway: A Novel Cross-Talk between Nutritional Obesity, Bariatric Surgery and Taste of Fat
Sign Up to like & getrecommendations! Published in 2021 at "Nutrients"
DOI: 10.3390/nu13041366
Abstract: Diet-induced obesity (DIO) reduces the orosensory perception of lipids in rodents and in some humans. Although bariatric surgery partially corrects this alteration, underlying mechanisms remain poorly understood. To explore whether metabolic changes might explain this… read more here.
Keywords: taste; tryptophan kynurenine; bariatric surgery; fat taste ... See more keywords