Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204006
Abstract: Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known to protect tumour cells from ferroptosis upon cysteine starvation through transamination.… read more here.
Keywords: metabolism; ferroptotic pathway; new anti; tryptophan metabolism ... See more keywords
Suicidality and Activation of the Kynurenine Pathway of Tryptophan Metabolism.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2016_5
Abstract: A recent report by the World Health Organization declared suicide to be a major global problem. With more than 800,000 lives lost each year, suicide is calculated to be the 14th leading cause of death… read more here.
Keywords: pathway tryptophan; tryptophan metabolism; pathway; kynurenine pathway ... See more keywords
Tyrosine kinase inhibitors modulate dendritic cell activity via confining c-Kit signaling and tryptophan metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106357
Abstract: Dendritic cell (DC)-based vaccine has been established in tumor immunotherapy. Importantly, the efficiency of anti-tumor T-cells in draining lymph nodes is dependent on the status of DCs surrounding in tumors. It has been shown that… read more here.
Keywords: kinase inhibitors; dcs; tryptophan metabolism; tyrosine kinase ... See more keywords
Latent toxoplasmosis and psychiatric symptoms - A role of tryptophan metabolism?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2018.12.016
Abstract: Toxoplasma gondii (TOX) is a common parasite which infects approximately one third of the human population. In recent years, it has been suggested that latent toxoplasmosis may be a risk factor for the development of… read more here.
Keywords: latent toxoplasmosis; metabolism; anxiety; psychiatric symptoms ... See more keywords
Tryptophan metabolism and immune regulation in the human placenta.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2021.103361
Abstract: The placenta represents the maternal-fetal vascular interface. It is capable of supplying the bioenergetic needs of the developing conceptus. It is composed of different cell types that engage in highly varied functions, ranging from attachment,… read more here.
Keywords: tryptophan; placenta; metabolism immune; tryptophan metabolism ... See more keywords
Acute liver failure increases kynurenic acid production in rat brain via changes in tryptophan metabolism in the periphery
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.02.004
Abstract: The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor and N-methyl-d-aspartic acid receptor at endogenous brain concentrations. Recent studies have suggested that increased brain KYNA levels are involved… read more here.
Keywords: tryptophan metabolism; kyna; kynurenic acid; brain ... See more keywords
Tryptophan Metabolism as a Pharmacological Target.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2020.11.006
Abstract: L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action mechanisms. Enzymes involved… read more here.
Keywords: metabolism; tryptophan metabolism; metabolism pharmacological; pharmacological target ... See more keywords
P.2.b.033 Childhood trauma affects tryptophan metabolism in mood disorder
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/s0924-977x(17)31455-4
Abstract: R. Bonsignori1, S. Poletti1, M. Riberto1, G. Schüetze2, C. Locatelli1, M. Schwarz2, F. Benedetti1. 1IRCCS Ospedale San Raffaele, Department of Clinical Neurosciences, Milan, Italy. 2Ludwig-Maximilian University, Institute for Laboratory Medicine of Munich University, Munich, Germany.… read more here.
Keywords: childhood trauma; affects tryptophan; trauma affects; tryptophan metabolism ... See more keywords
Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01883
Abstract: Pu-erh tea is a healthy beverage rich in phytochemicals, and its effect on the risk of inducing circadian rhythm disorders (CRD) is unclear. In this study, healthy mice were given water or 0.25% (w/v) Pu-erh… read more here.
Keywords: tryptophan metabolism; disruption; erh tea; tea ... See more keywords
Dietary Turmeric Consumption Alleviates Ulcerative Colitis via Restoring Tryptophan Metabolism and Alleviating Gut Microbiota Dysbiosis in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04509
Abstract: This study was designed to first verify the protective capacity of turmeric powder (TP) as a traditional cooking spice against dextran sulfate sodium (DSS)-induced intestinal inflammation and intestine microbiota imbalance. The DSS-induced mice were fed… read more here.
Keywords: metabolism; consumption; tryptophan metabolism; microbiota dysbiosis ... See more keywords
Honeybee gut Lactobacillus modulates host learning and memory behaviors via regulating tryptophan metabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29760-0
Abstract: Honeybees are highly social insects with a rich behavioral repertoire and are a versatile model for neurobiological research. Their gut microbiota comprises a limited number of host-restricted bacterial phylotypes that are important for honeybee health.… read more here.
Keywords: learning memory; memory; tryptophan metabolism; gut ... See more keywords