Tryptophan metabolite atlas uncovers organ, age, and sex-specific variations.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS open bio"
DOI: 10.1002/2211-5463.70123
Abstract: Tryptophan (Trp) is the largest and most structurally complex amino acid, yet it is the least abundant in the proteome. Its distinct indole ring and high carbon content allow it to give rise to several… read more here.
Keywords: age; metabolite atlas; trp metabolites; sex ... See more keywords
The microbiota-dependent tryptophan metabolite alleviates high-fat diet–induced insulin resistance through the hepatic AhR/TSC2/mTORC1 axis
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2400385121
Abstract: Significance High-fat diet (HFD) causes the dysbiosis of the gut microbiota, which influences the host glucose metabolism and thus leads to type 2 diabetes (T2D). Determination of the microbial metabolism pathway and certain agents contributing… read more here.
Keywords: microbiota dependent; fat diet; tryptophan metabolite; hiaa ... See more keywords
The Gut Microbiota Activates AhR Through the Tryptophan Metabolite Kyn to Mediate Renal Cell Carcinoma Metastasis
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DOI: 10.3389/fnut.2021.712327
Abstract: Background: The incidence of renal cell carcinoma (RCC) is increasing year by year. It is difficult to have complete treatment so far. Studies have shown that tryptophan metabolite Kynurenine (Kyn) affects cell proliferation, migration, apoptosis,… read more here.
Keywords: 786 cells; metabolite kyn; tryptophan metabolite; kyn ... See more keywords
The Tryptophan Metabolite Indole-3-Carboxaldehyde Alleviates Mice with DSS-Induced Ulcerative Colitis by Balancing Amino Acid Metabolism, Inhibiting Intestinal Inflammation, and Improving Intestinal Barrier Function
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093704
Abstract: Ulcerative colitis (UC) has attracted much attention for its negative influence on quality of life and increased risk of colorectal cancer. Chemical and biological drugs are currently the usual treatment for UC. These drugs always… read more here.
Keywords: metabolism; dss induced; colitis; tryptophan metabolite ... See more keywords