Chromatographic analysis of tryptophan metabolites
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Separation Science"
DOI: 10.1002/jssc.201700184
Abstract: The kynurenine pathway generates multiple tryptophan metabolites called collectively kynurenines and leads to formation of the enzyme cofactor nicotinamide adenine dinucleotide. The first step in this pathway is tryptophan degradation, initiated by the rate‐limiting enzymes… read more here.
Keywords: analysis tryptophan; chromatographic analysis; tryptophan metabolites; tryptophan ... See more keywords
Shenling Baizhu San ameliorates ulcerative colitis by regulating the gut microbiota and its tryptophan metabolites: A complementary medicine to mesalamine.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115145
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Shenling Baizhu San (SBS) is commonly employed to improve gastrointestinal dysfunction in patients with ulcerative colitis (UC) in China. SBS combined with mesalamine has been demonstrated to result in improve its curative effects… read more here.
Keywords: shenling baizhu; tryptophan metabolites; mesalamine; medicine ... See more keywords
Application of the optimized and validated LC-MS method for simultaneous quantification of tryptophan metabolites in culture medium from cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.112805
Abstract: Kynurenine pathway is the main route of tryptophan degradation generating a number of immunoregulatory compounds. Some conditions like oxidative stress, inflammatory factors might enhance tryptophan degradation. Process is active in several cells including fibroblasts, cancer… read more here.
Keywords: tryptophan metabolites; tryptophan; simultaneous quantification; cancer ... See more keywords
Enhanced Intestinal Barriers by Puerarin in Combination with Tryptophan.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c05830
Abstract: The intestinal barrier is essential for maintaining human intestinal health. The growing number of studies has shown that both puerarin and tryptophan and its metabolites have a beneficial effect on the intestinal barrier. This study… read more here.
Keywords: puerarin tryptophan; combination; tryptophan; tryptophan metabolites ... See more keywords
The Tryptophan Pathway Targeting Antioxidant Capacity in the Placenta
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/1054797
Abstract: The placenta plays a vital role in fetal development during pregnancy. Dysfunction of the placenta can be caused by oxidative stress and can lead to abnormal fetal development. Preventing oxidative stress of the placenta is… read more here.
Keywords: tryptophan pathway; antioxidant capacity; tryptophan metabolites; antioxidant properties ... See more keywords
High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1366-3
Abstract: BackgroundThe host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces the activation… read more here.
Keywords: tryptophan metabolites; nervous system; central nervous; neurotoxic tryptophan ... See more keywords
Metabonomics reveals that entomopathogenic nematodes mediate tryptophan metabolites that kill host insects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1042145
Abstract: The entomopathogenic nematode (EPN) Steinernema feltiae, which carries the symbiotic bacterium Xenorhabdus bovienii in its gut, is an important biocontrol agent. This EPN could produce a suite of complex metabolites and toxin proteins and lead… read more here.
Keywords: kill host; insects; host insects; metabonomics reveals ... See more keywords
Tryptophan Metabolites as Mediators of Microbiota-Gut-Brain Communication: Focus on Isatin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.922274
Abstract: Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of the indole nucleus. Although these… read more here.
Keywords: mediators microbiota; brain; isatin; microbiota gut ... See more keywords
Tryptophan metabolites in depression: Modulation by gut microbiota
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.987697
Abstract: Clinical depression is a multifactorial disorder and one of the leading causes of disability worldwide. The alterations in tryptophan metabolism such as changes in the levels of serotonin, kynurenine, and kynurenine acid have been implicated… read more here.
Keywords: gut; modulation; depression; etiology ... See more keywords
Tryptophan Metabolites at the Crossroad of Immune-Cell Interaction via the Aryl Hydrocarbon Receptor: Implications for Tumor Immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094644
Abstract: The Aryl hydrocarbon receptor (AhR) is a critical regulator of both innate and adaptive immune responses, with potent immunomodulatory effects that makes this receptor an attractive molecular target for novel therapeutics. Accumulating evidence indicates that… read more here.
Keywords: immune; tryptophan metabolites; hydrocarbon receptor; aryl hydrocarbon ... See more keywords
Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042369
Abstract: In patients with chronic kidney disease (CKD) and in animal models of CKD, the transcription factor Aryl Hydrocabon Receptor (AhR) is overactivated. In addition to the canonical AhR targets constituting the AhR signature, numerous other… read more here.
Keywords: nptx1 expression; endothelial cells; expression; ahr ... See more keywords