Aqueous Flavin Photoredox Catalysis Drives Exclusive C3-Alkylation of Indolyl Radical Cations in Route to Unnatural Tryptophan Mimetics.
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DOI: 10.1021/acs.orglett.3c01398
Abstract: One way to build chemical diversity into indoles is to oxidize them to indolyl radical cations (Ind•+). These intermediates can accept new functional groups across C2-C3 bonds or independently at C2. Less encountered is selective… read more here.
Keywords: indolyl radical; alkylation; flavin photoredox; tryptophan mimetics ... See more keywords