Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators
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DOI: 10.3390/ph16020146
Abstract: For the first time, the pharmacokinetic (PK) profile of tryptophanol-derived isoindolinones, previously reported as p53 activators, was investigated. From the metabolites’ identification, performed by liquid chromatography coupled to high resolution tandem mass spectrometry (LC-HRMS/MS), followed… read more here.
Keywords: metabolism; p53 activators; tryptophanol; tryptophanol derived ... See more keywords