Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Diversity"
DOI: 10.1007/s11030-019-10011-2
Abstract: In the current study, we used an integrated approach combining bioinformatics, rational drug design, one-pot synthesis, and biological experiments in vitro for the potential discovery of novel tryptophanyl-tRNA synthetase (TrpRS) inhibitors. Atom economic and diastereoselective… read more here.
Keywords: indenoquinoxaline; tryptophanyl trna; spirooxindole indenoquinoxaline; novel tryptophanyl ... See more keywords
Establishment of Inhibitor Screening and Validation System for Tryptophanyl tRNA Synthetase Using Surface Plasmon Resonance.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114183
Abstract: With the increase in throughput and sensitivity, biophysical technology has become a major component of the early drug discovery phase. Surface plasmon resonance technology (SPR) is one of the most widely used biophysical technologies. It… read more here.
Keywords: tryptophanyl trna; trna synthetase; surface plasmon; validation system ... See more keywords
Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2019.1596086
Abstract: Abstract The rapid emergence of bacterial resistance to antibiotics currently available for treating infectious diseases requires effective antimicrobial agents with new structural profiles and mechanisms of action. Twenty-three thiazolin-4-one derivatives were evaluated for their antibacterial… read more here.
Keywords: tryptophanyl trna; thiazolin one; one derivatives; trna synthetase ... See more keywords
Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target
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DOI: 10.3390/ijms22094523
Abstract: Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNAtrp during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune… read more here.
Keywords: tryptophanyl trna; target; trna synthetase; potential therapeutic ... See more keywords