Parkin is downregulated among autophagy-related proteins prior to hyperphosphorylation of Tau in TS65DN mice.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.05.016
Abstract: Autophagy is a pathway through which cells execute a plethora of functions, such as macromolecules and organelles quality control, recycling of building blocks and apoptosis. Numerous studies have shown in the past that autophagy is… read more here.
Keywords: related proteins; hyperphosphorylation tau; ts65dn mice; autophagy related ... See more keywords
Daunorubicin-induced arterial stiffness in Down syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733537
Abstract: Children with Down syndrome have a high risk of leukemia and are at a higher risk for delayed early onset heart failure after treatment. Cardiac toxicity is more severe in female patients. Traditional risk factors… read more here.
Keywords: ts65dn mice; ts65dn; daunorubicin; physiology ... See more keywords
Early Appearance of Dendritic Alterations in Neocortical Pyramidal Neurons of the Ts65Dn Model of Down Syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Neuroscience"
DOI: 10.1159/000520925
Abstract: Down syndrome (DS), which is due to triplication of chromosome 21, is constantly associated with intellectual disability (ID). ID can be ascribed to both neurogenesis impairment and dendritic pathology. These defects are replicated in the… read more here.
Keywords: dendritic alterations; pyramidal neurons; ts65dn model; pathology ... See more keywords
Emergence of Treadmill Running Ability and Quantitative Assessment of Gait Dynamics in Young Ts65Dn Mice: A Mouse Model for Down Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13050743
Abstract: Down syndrome (DS), which results from the complete or partial trisomy of chromosome 21 (trisomy-21), is the most common genetically defined cause of intellectual disability. Trisomy-21 also produces, or is associated with, many neurodevelopmental phenotypes… read more here.
Keywords: ts65dn mice; mouse; model; mice ... See more keywords