Temporal and brain region‐specific elevations of soluble Amyloid‐β40‐42 in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13590
Abstract: Down syndrome (DS) is a leading cause of intellectual disability that also results in hallmark Alzheimer's disease (AD) pathologies such as amyloid beta (Aβ) plaques and hyperphosphorylated tau. The Ts65Dn mouse model is commonly used… read more here.
Keywords: ts65dn; alzheimer disease; region; model ... See more keywords
Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Neural Plasticity"
DOI: 10.1155/2018/9235796
Abstract: The Ts65Dn mouse is the most studied animal model of Down syndrome. Past research has shown a significant reduction in CA1 hippocampal long-term potentiation (LTP) induced by theta-burst stimulation (TBS), but not in LTP induced… read more here.
Keywords: ltp; ca1 hippocampal; ts65dn mouse; ts65dn ... See more keywords
Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurodevelopmental Disorders"
DOI: 10.1186/s11689-019-9294-9
Abstract: BackgroundDown syndrome (DS), caused by the triplication of chromosome 21, results in a constellation of clinical features including changes in intellectual and motor function. Although altered neural development and function have been well described in… read more here.
Keywords: ts65dn mouse; motor; mouse model; development ... See more keywords
Noninvasive assessment of autonomic modulation of heart rate variability in the Ts65Dn mouse model of Down syndrome: A proof of principle study
Sign Up to like & getrecommendations! Published in 2020 at "Physiological Reports"
DOI: 10.14814/phy2.14486
Abstract: The Ts65Dn mouse is the most widely used animal model of Down syndrome (DS). Differences in autonomic regulation of heart rate variability (HRV) in individuals with DS have been hypothesized. Pharmacological studies in animal models… read more here.
Keywords: rate variability; heart rate; model syndrome; ts65dn mouse ... See more keywords