Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2016.12.009
Abstract: Metformin is the most widely prescribed drug for the treatment of type 2 diabetes. However, knowledge of the full effects of metformin on biochemical pathways and processes in its primary target tissue, the liver, is limited. One… read more here.
Keywords: hepatic mtorc1; tsc complex; mtorc1 signaling; metformin ... See more keywords
Structural insights into TSC complex assembly and GAP activity on Rheb
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DOI: 10.1038/s41467-020-20522-4
Abstract: Tuberous sclerosis complex (TSC) integrates upstream stimuli and regulates cell growth by controlling the activity of mTORC1. TSC complex functions as a GTPase-activating protein (GAP) towards small GTPase Rheb and inhibits Rheb-mediated activation of mTORC1.… read more here.
Keywords: gap; tsc complex; tsc; tsc2 ... See more keywords