Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation
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DOI: 10.1038/s41420-020-0285-0
Abstract: Tuberous sclerosis complex (TSC) is characterized by hamartomatous lesions in multiple organs, with most patients developing polycystic kidney disease and leading to a decline of renal function. TSC is caused by loss-of-function mutations in either… read more here.
Keywords: ampk phosphorylation; metformin; pathology; tsc1 deletion ... See more keywords