Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ)
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DOI: 10.1038/s41388-019-0957-5
Abstract: miR-29b has been identified as a rapamycin-induced microRNA (miRNA) in Tsc2-deficient, mTORC1-hyperactive cells. The biological significance of this induction of miR-29b is unknown. We have found that miR-29b acts as an oncogenic miRNA in Tsc2-deficient… read more here.
Keywords: rar; deficient cells; mir 29b; cell ... See more keywords
Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells
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DOI: 10.1371/journal.pone.0228894
Abstract: Lymphangioleiomyomatosis (LAM) is a devastating lung disease caused by inactivating gene mutations in either TSC1 or TSC2 that result in hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1). As LAM occurs predominantly in… read more here.
Keywords: pyruvate kinase; lam; pkm2; estrogen ... See more keywords
Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R
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DOI: 10.18632/oncotarget.17485
Abstract: Tuberous sclerosis complex (TSC) is a multisystem disease associated with hyperactive mTORC1. The impact of TSC1/2 deficiency on lysosome-mediated processes is not fully understood. We report here that inhibition of lysosomal function using chloroquine (CQ)… read more here.
Keywords: tuberous sclerosis; sclerosis complex; cholesterol homeostasis; cholesterol ... See more keywords