A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients
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DOI: 10.1080/2162402x.2018.1426423
Abstract: ABSTRACT Adult T-cell leukemia (ATL) is an aggressive, chemotherapy-resistant CD4+CD25+ leukemia caused by HTLV-1 infection, which usually develops in a minority of patients several decades after infection. IFN + AZT combination therapy has shown clinical… read more here.
Keywords: fas; apoptosis; ifn; tscm ... See more keywords
Correlation of T cell fitness of apheresis products with response to CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma: A prospective observational study at a single center
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DOI: 10.1182/blood-2025-1930
Abstract: Background CD19-directed chimeric antigen receptor (CAR) T-cells have revolutionized the treatment of relapsed/refractory large B-cell lymphoma (r/r LBCL). However, long-term remissions are observed in less than half of patients. Mechanisms of resistance include tumor intrinsic… read more here.
Keywords: cell therapy; tscm; car cell; car ... See more keywords
TIM3-Galectin9 axis drives CSF-1R–independent senescent macrophage and TSCM crosstalk in chronic graft-versus-host disease
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DOI: 10.1182/blood-2025-4085
Abstract: Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity post-allogeneic hematopoietic cell transplantation. Despite CSF-1R blockade depleting pro-fibrogenic macrophages, ~30% of cGVHD patients remain refractory, highlighting an urgent need to identify resistance mechanisms and… read more here.
Keywords: cgvhd; tscm; macrophage; csf ... See more keywords