Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101453
Abstract: Currently, most antioxidants do not show any favorable clinical outcomes in reducing myocardial ischemia-reperfusion (I/R) injury, suggesting an urgent need for exploring a new regulator of redox homeostasis in I/R hearts. Here, using heart-specific transgenic… read more here.
Keywords: p62 keap1; keap1 nrf2; tsg101 positively; positively regulates ... See more keywords
TSG101 negatively regulates mitochondrial biogenesis in axons
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2018770118
Abstract: Significance Mitochondrial dysfunction has been associated with many age-dependent neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease, yet understanding how a neuron maintains a pool of functional mitochondria in sufficient density and location throughout axons… read more here.
Keywords: mitochondrial biogenesis; biogenesis; regulates mitochondrial; mitochondrial number ... See more keywords
Tumor Susceptibility Gene 101 (TSG101) Contributes to Virion Formation of Porcine Reproductive and Respiratory Syndrome Virus via Interaction with the Nucleocapsid (N) Protein along with the Early Secretory Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00005-22
Abstract: PRRSV infection results in a serious swine disease affecting pig farming in the world. However, efficient prevention and control of PRRSV is hindered by its complicated infection process. ABSTRACT Porcine reproductive and respiratory syndrome virus… read more here.
Keywords: along early; prrsv infection; prrsv; infection ... See more keywords
The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease
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DOI: 10.3390/cancers12020450
Abstract: The multidomain protein encoded by the Tumor Susceptibility Gene 101 (TSG101) is ubiquitously expressed and is suggested to function in diverse intracellular processes. In this review, we provide a succinct overview of the main structural… read more here.
Keywords: 101 tsg101; susceptibility gene; tsg101; gene 101 ... See more keywords
Epstein-Barr Virus Enhances Cancer-Specific Aberrant Splicing of TSG101 Pre-mRNA
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052516
Abstract: Tumor viruses gain control of cellular functions when they infect and transform host cells. Alternative splicing is one of the cellular processes exploited by tumor viruses to benefit viral replication and support oncogenesis. Epstein-Barr virus… read more here.
Keywords: tsg101 154; ebv; epstein barr; tsg101 ... See more keywords
RNA Binding Suppresses Tsg101 Recognition of Ub-Modified Gag and Facilitates Recruitment to the Plasma Membrane
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12040447
Abstract: The ESCRT-I factor Tsg101 is essential for sorting endocytic cargo and is exploited by viral pathogens to facilitate egress from cells. Both the nucleocapsid (NC) domain and p6 domain in HIV-1 Gag contribute to recruitment… read more here.
Keywords: gag; rna binding; recognition modified; membrane ... See more keywords